Results 21 to 30 of about 99,653 (320)

Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI.

Journal of the American Society of Nephrology, 2020
BACKGROUND AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, and coagulation, and soluble ...
T. Azam, Husam Shadid, P. Blakely, Patrick J O'Hayer, Hanna Berlin, Michael Pan, Peiyao Zhao, Lili Zhao, S. Pennathur, R. Pop-Busui, I. Altintas, J. Tingleff, M. Stauning, O. Andersen, M. Adami, N. Solomonidi, M. Tsilika, P. Tober-Lau, E. Arnaoutoglou, V. Keitel, F. Tacke, A. Chalkias, S. Loosen, E. Giamarellos‐Bourboulis, J. Eugen-Olsen, J. Reiser, S. Hayek   +26 more
semanticscholar   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Outcomes and Treatment Complications of Intravenous Urokinase Thrombolysis in Acute Ischemic Stroke in China

Frontiers in Neurology, 2021
Background: Intravenous thrombolysis with alteplase benefits eligible patients with acute ischemic stroke. However, in some countries such as China, alteplase may be too expensive for low-income patients, and also for regions with low economic ...
Rongrong Zhang, Hui Wei, Yu Ren, Yanping Wu, Yetao Luo, Lei Zhang, Yingchao Huo, Jinzhou Feng, Philippe P. Monnier, Philippe P. Monnier, Philippe P. Monnier, Xinyue Qin   +11 more
doaj   +1 more source

Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]

, 2003
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Behrendt N., Bianchi E., Borglum A.D., Boyd D., Chapman H.A., Conese M., Cubellis M.V., Duffy M.J., Duffy M.J., Ellis V., Hollas W., Kariko K., Kook Y.H., Lakka S.S., Langer D.J., Leupold J.H., Lund L.R., Means A.L., Min H.Y., Mohanam S., Nekarda H., Pedersen H., Pyke C., Pyke C., Quattrone A., Resnati M., Roldan A., Schewe D., Shetty S., Soravia E., Suh T., Xue W.   +31 more
core   +1 more source

Functional, pathogenic, and pharmacological roles of protein folding intermediates

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
wiley   +1 more source

Intrapleural Fibrinolysis with Urokinase versus Alteplase in Complicated Pleural Effusions and Empyema: A Prospective Randomized Controlled Trial [PDF]

Tuberculosis and Respiratory Diseases
Background Intrapleural fibrinolytic therapy (IPFT) has been used as an effective agent since 1949 for managing complicated pleural effusion and empyema. Several agents, such as streptokinase, urokinase (UK), and recombinant tissue plasminogen activator (
Sudipt Adhikari, Vikas Marwah, Robin Choudhary, Indermani Pandey, Tentu Ajai Kumar, Virender Malik, Arpita Pemmaraju, Shrinath Vasudevan, Suraj Kapoor   +8 more
doaj   +1 more source

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes [PDF]

, 2012
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes.
Baretton, Gustavo, Grismayer, Bettina, Kopitz, Charlotte, Kotzsch, Matthias, Krueger, Achim, Luther, Thomas, Magdolen, Viktor, Ries, Christian, Sato, Sumito, Schmitt, Manfred, Soelch, Susanne   +10 more
core   +1 more source

Fibrinolysis versus thoracoscopy: Comparison of results in empyema management in the child

Annals of Thoracic Medicine, 2022
OBJECTIVE: The objective of this study is to compare the outcome of treatment with drainage and urokinase (UK) versus thoracoscopy (TS) in pleural empyema secondary to complicated pneumonia.
Maria Rosa Ibarra Rodriguez, Jose Ignacio Garrido Pérez, Fernando Vázquez Rueda, Francisco Javier Murcia Pascual, Sandra Rocio Wiesner Torres, Rosa Maria Paredes Esteban   +5 more
doaj   +1 more source

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

Frontiers in Oncology, 2018
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes.
Niaz Mahmood, C. Mihalcioiu, S. Rabbani
semanticscholar   +1 more source

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Arroyo de Prada, Nuria, Bürgle, Markus, Degitz, Klaus, Kellermann, Josef, Kessler, Horst, Magdolen, Viktor, Riemer, Christoph, Schmiedeberg, Niko, Schmitt, Manfred, Schroeck, Florian, Wilhelm, Olaf G.   +10 more
core   +1 more source