Results 61 to 70 of about 99,653 (320)

Hippocampal Viral-Mediated Urokinase Plasminogen Activator (uPA) Overexpression Mitigates Stress-Induced Anxiety and Depression in Rats by Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels

Biomolecules
Emerging evidence suggests the serine protease, urokinase plasminogen activator (uPA), may play an important role in the modulation of mood and cognitive functions. Also, preliminary evidence indicates that uPA modulates BDNF activity that is known to be
Amine Bahi, Jean-Luc Dreyer
doaj   +1 more source

Intrapleural Instillation of Sodium Bicarbonate versus Urokinase in Management of Complicated Pleural Effusion: A Comparative Cohort Study

International Journal of General Medicine, 2022
Niveen E Zayed,1 Karim El Fakharany,2 Mohammed Mehriz Naguib Abozaid1 1Department of Chest Disease, Faculty of Medicine, Zagazig University, Zagazig City, Egypt; 2Department of Cardiothoracic Surgery, Faculty of Medicine, Zagazig University, Zagazig City,
Zayed NE, El Fakharany K, Mehriz Naguib Abozaid M   +2 more
doaj  

A study of the interaction between Helicobacter pylori and components of the human fibrinolytic system

Brazilian Journal of Medical and Biological Research, 2000
The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal, L. Avilán, K. Hoelzl, M. de Muñoz, J. Puig, I. Kansau   +5 more
doaj   +1 more source

MicroRNA 449a can Attenuate Protective Effect of Urokinase Against Pulmonary Embolism

Frontiers in Pharmacology, 2022
Acute pulmonary embolism (APE) is a disabling diseases with high incidence rate and mortality rate. Although with high specificity, D-Dimer lacks specificity to assess APE, hence additional diagnostic and prognostic biomarkers are necessary.
Ran Zhu, Wei-yi Qi, Ting-wei Liu, Fan Liu   +3 more
doaj   +1 more source

Editor's choice : European Society for Vascular Surgery (ESVS) 2020 clinical practice guidelines on the management of acute limb ischaemia

, 2020
A
Acosta, Stefan, Azuma, Nobuyoshi, Bastos Gonçalves, Frederico, Björck, Martin, Boyle, Jonathan R., Chakfé, Nabil, Choke, Edward T. C., Cochennec, Frederic, Cohnert, Tina U., de Borst, Gert J., Document Reviewers, Earnshaw, Jonothan J., ESVS Guidelines Committee, Fitridge, Robert A., Forbes, Thomas L., Hamady, Mohamad S., Hinchliffe, Robert, Jongkind, Vincent, Kakkos, Stavros K., Koelemay, Mark J. W., Koncar, Igor, Lindholt, Jes S., Mani, Kevin, Menyhei, Gabor, Munoz, Alberto, Müller-Hülsbeck, Stefan, Rai, Kumud, Sebastian Debus, E., Svetlikov, Alexei V., Tshomba, Yamume, Tulamo, Riikka, van den Berg, Jos C., Vega de Ceniga, Melina, Vermassen, Frank   +33 more
core   +2 more sources

Rapid Blood Clot Removal via Remote Delamination and Magnetization of Clot Debris

Advanced Science, EarlyView.
A programmable colloidal microswarm is developed to quickly detach blood clots and enable rapid recanalization, with the detached debris functioning as a magnetic “debris‐robot” that can be efficiently propelled and retrieved via catheter suction, which could significantly save time compared to the critical “Golden 6 hours” window for ischemic stroke ...
Qinglong Wang, Ben Wang, Kai Fung Chan, Xin Song, Qianqian Wang, Fengtong Ji, Lin Su, Bonaventure Yiu Ming Ip, Ho Ko, Philip Wai Yan Chiu, Thomas Wai Hong Leung, Li Zhang   +11 more
wiley   +1 more source

Fibrinolytics: from the thrombolysis to the processes of blood vessels growth and remodeling, neurogenesis, carcinogenesis and fibrosis [PDF]

Терапевтический архив, 2019
One of the most outstanding scientific achievements in the thrombolysis is the development and administration of fibrinolysin - the first Soviet drug that lyses blood clots.
V A Tkachuk, Ye V Parfyonova, O S Plekhanova, V V Stepanova, M Yu Menshikov, E V Semina, R Sh Bibilashvili, E I Chazov   +7 more
doaj   +1 more source

Poly-α, β-d, l-Aspartyl-Arg-Gly-Asp-Ser-Based Urokinase Nanoparticles for Thrombolysis Therapy

Molecules, 2023
The most concerning adverse effects of thrombolytic agents are major bleeding and intracranial hemorrhage due to their short half-life, low fibrin specificity, and high dosage.
Shuangling Chen, Meng Liang, Chengli Wu, Xiaoyi Zhang, Yuji Wang, Ming Zhao   +5 more
doaj   +1 more source

Measuring the metastatic potential of cancer cells [PDF]

, 1993
Cancer cells must secrete proteolytic enzymes to invade adjacent tissues and migrate to a new metastatic site. Urokinase (uPA) is a key enzyme related to metastasis in cancers of the lung, colon, gastric, uterine, breast, brain, and malignant melanoma. A
Atassi, M. Z., Gratzner, Howard, Morrison, Dennis R.   +2 more
core   +1 more source

Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells [PDF]

, 2015
: BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal ...
Baltus, Christine B, Chuckowree, Irina S, Librizzi, Mariangela, Longo, Alessandra, Luparello, Claudio, Spencer, John   +5 more
core   +2 more sources