Results 71 to 80 of about 99,653 (320)

Proteolytic Regulation of Epithelial Sodium Channels by Urokinase Plasminogen Activator

Journal of Biological Chemistry, 2015
Background: Depressed fibrinolysis and edema concurrently exist in edematous injury. Results: Divergent regulation of ENaC by urokinase and tPA was observed. Both the catalytic domain of urokinase and cleavage sites in ENaC were identified.
H. Ji, Runzhen Zhao, A. Komissarov, Yongchang Chang, Yongfeng Liu, M. Matthay   +5 more
semanticscholar   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Predicting Mortality in African Americans With Type 2 Diabetes Mellitus: Soluble Urokinase Plasminogen Activator Receptor, Coronary Artery Calcium, and High‐Sensitivity C‐Reactive Protein

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundType 2 diabetes mellitus is a major risk factor for cardiovascular disease; however, outcomes in individual patients vary. Soluble urokinase plasminogen activator receptor (suPAR) is a bone marrow–derived signaling molecule associated with ...
Salim S. Hayek, Jasmin Divers, Mohamad Raad, Jianzhao Xu, Donald W. Bowden, Melissa Tracy, Jochen Reiser, Barry I. Freedman   +7 more
doaj   +1 more source

2016—2022年中国急性缺血性卒中静脉溶栓趋势及阿替普酶与尿激酶静脉溶栓院内结局比较分析 Trend of Intravenous Thrombolysis and a Comparative Analysis of In-hospital Outcomes of Intravenous Thrombolysis with Alteplase or Urokinase in Acute Ischemic Stroke in China from 2016 to 2022

Zhongguo cuzhong zazhi, 2023
目的 评估我国2016—2022年发病6 h内急性缺血性卒中患者静脉溶栓的变化趋势，并比较rt-PA与尿激酶静脉溶栓的院内临床结局差异。 方法 纳入中国卒中中心联盟（Chinese Stroke Center Alliance，CSCA）2016年1月—2022年12月登记的发病6 h内到院的急性缺血性卒中患者555 991例，计算各年份rt-PA静脉溶栓和尿激酶静脉溶栓的比例变化。采用多因素logistic回归法，以rt-PA溶栓为对照，分析尿激酶溶栓对院内脑梗死出血转化 ...
宗黎霞1，谷鸿秋2，杨昕2，姜英玉2，李子孝1，2，王春娟1，2
doaj   +1 more source

Evaluating the expression of urokinase and tissue leukocyte being in benign and malignant breast disease [PDF]

, 2018
Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Costi, U., De SAntis, A., Gabriele, R., Izzo, L., Izzo, P., Izzo, S., Pagni, P., Pugliese, F., Spunticchia, F.   +8 more
core  

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Intra-arterial thrombolysis for acute ischemic stroke: Our institutional experience

Indian Journal of Neurosurgery, 2012
Introduction The standard treatment for acute ischemic stroke is intravenous (IV) rtPA for patients who can reach the hospital within 3 to 4.5 h. There are case reports, where IA thrombolysis has helped patients in case an IV thrombolysis has failed.
R.V. Narayana, Rajesh Pati, Sibasankar Dalai   +2 more
doaj   +1 more source

A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease

Kidney International, 2014
It has been suggested that soluble urokinase receptor (suPAR) is a causative circulating factor for and a biomarker of focal and segmental glomerulosclerosis (FSGS).
Joann M. Spinale, L. Mariani, S. Kapoor, Jidong Zhang, R. Weyant, P. Song, Hetty N. Wong, J. Troost, C. Gadegbeku, D. Gipson, M. Kretzler, D. Nihalani, L. Holzman   +12 more
semanticscholar   +1 more source

Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex

Advanced Science, EarlyView.
Cu2Ir NPs based on a Cu‐porphyrin core and cyclometalated Ir(III) substituents achieve combined endogenous peroxynitrite‐triggered NIR chemiluminescence imaging, PTT and PDT for successfully achieving safe thrombolysis, antioxidant and anti‐inflammatory multifunctionality in one single molecule.
Ziwei Wang, Bo Zhu, Wenxin Nie, Liping Zhang, Nan Xiao, Qiaohua Zhang, Zihan Wu, Chunguang Shi, Weijin Zhu, Qianwen Liu, Dongxia Zhu, Martin R. Bryce, Lijie Ren, Ben Zhong Tang   +13 more
wiley   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source