Results 61 to 70 of about 175,762 (228)

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Prognostic value of urokinase plasminogen activator for prostatic carcinoma.

, 1994
The usefulness of routine clinical application of the urokinase plasminogen activator in prostate cancer was evaluated. The urokinase values of prostate cancer confined to the organ, with extraprostatic spread and with metastatic disease did not differ ...
Plas E, Lehmann K, Hauri D, Gautschi K
core   +1 more source

QSAR modelling to predict structural features of certain sulfonamide as Urokinase-type Plasminogen Activator inhibitors

Chemical Physics Impact
The serine hydrolase family includes serine proteases. It is essential for hydrolyzing protein peptide bonds and breaking them. The urokinase-type plasminogen activator (uPA) selectively binds to the uPAR on numerous cell types, including cancer cells ...
Rahul D. Jawarkar, Magdi E.A. Zaki, Sami A. Al-Hussain, Abdullah Yahya Abdullah Alzahrani, Long Chiau Ming, Abdul Samad, Rahul G. Ingle, Suraj N. Mali   +7 more
doaj   +1 more source

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells

Biomarker Insights, 2017
The urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for various malignancies. The aim of this study is to assess the prognostic value of uPAR expression in neoplastic and stromal cells of patients with ...
Susanna WL de Geus, Victor M Baart, Martin C Boonstra, Peter JK Kuppen, Hendrica AJM Prevoo, Andrew P Mazar, Bert A Bonsing, Hans Morreau, Cornelis JH van de Velde, Alexander L Vahrmeijer, Cornelis FM Sier   +10 more
doaj   +1 more source

Evaluation of Urokinase Plasminogen Activator Receptor, Soluble Urokinase Plasminogen Activator Receptor, and β1 Integrin in Patients with Hodgkin′s Lymphoma

Advanced Biomedical Research, 2017
Background: The objective of this study is to indicate the role of urokinase plasminogen activator receptor (uPAR), soluble uPAR (suPAR), and β1 integrin in tumor growth and invasion of lymph nodes from Hodgkin's lymphoma (HL) patients.
Shirin Kouhpayeh, Alireza Andalib, Marjan Gharagozloo, Mohammad Hossein Sanei, Nafiseh Esmaeil, Mohammad Reza Maracy   +5 more
doaj   +1 more source

Prognostic effects of SuPAR and Neopterin Levels on Patients with Lung Cancer

Pteridines, 2020
Background: Two unique biomarkers, soluble form of the urokinase-type plasminogen activator receptor (suPAR) and neopterin, play a crucial role in inflammatory processes.
Yalcin Selim, Demir Mehmet Emin, Ozturk Reyhan, Kılınç Aytün Şadan, Suer Hatice, Karahan Irfan   +5 more
doaj   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Induction of Urokinase Activity by Retinoic Acid in Two Cell Lines of Neuronal Origin

Biomedicines, 2019
Retinoic acid is one of the most well-known agents able to induce differentiation in several types of tumours. Unfortunately, most of the tumours are refractive to the differentiation cues.
Luka Horvat, Josip Madunić, Martina Grubar, Mariastefania Antica, Maja Matulić   +4 more
doaj   +1 more source

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

Andrology, EarlyView.
ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni, Fiorella Di Nicuolo, Giorgia Mazzuccato, Alessandro Oliva, Emanuele Pierpaolo Vodola, Francesca Mancini, Carla Di Nardo, Edoardo Vergani, Michela Cicchinelli, Federica Iavarone, Cassandra Serantoni, Giuseppe Maulucci, Alessia Riente, Alfredo Pontecorvi, Andrea Urbani, Domenico Milardi, Silvia Baroni   +16 more
wiley   +1 more source

Tumor markers in breast cancer - European Group on Tumor Markers recommendations [PDF]

, 2005
Recommendations are presented for the routine clinical use of serum and tissue-based markers in the diagnosis and management of patients with breast cancer.
Einarsson, Roland, Barak, Vivian, Dalen, Arie van, Duffy, Michael J., Nap, Marius, Gion, Massimo, Molina, Rafael, Lamerz, Rolf, Sölétormos, György, Goike, Helena, Stieber, Petra   +10 more
core   +1 more source