Results 101 to 110 of about 1,484,561 (230)

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch, Kraiczy Peter, Böhm Sascha, van den Elsen Jean, Koch Tina K., Skerka Christine, Reuter Michael, Zipfel Peter F., Barthel Diana   +25 more
core   +1 more source

BIOCHEMICAL MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS IN ATHEROSCLEROSIS AND THE GENES RESPONSIBLE FOR THEIR REGULATION

Атеросклероз, 2017
The review systematized modern concepts of markers of endothelial dysfunction and disorders of hemostasis (asymmetric dimethylarginine, endothelin 1, adhesive ICAM and VCAM molecules, apolipoproteins, antithrombin III, receptor of urokinase plasminogen ...
E. V. Stryukova, Yu. I. Ragino, V. N. Maksimov   +2 more
doaj  

Soluble urokinase plasminogen activator receptor for the prediction of ventilator-associated pneumonia

ERJ Open Research, 2019
Introduction Diagnosing ventilator-associated pneumonia (VAP) remains challenging. Soluble urokinase plasminogen activator receptor (suPAR) has prognostic value in critically ill patients with systemic infection.
Pouline M. van Oort, Lieuwe D. Bos, Pedro Póvoa, Paula Ramirez, Antoni Torres, Antonio Artigas, Marcus J. Schultz, Ignacio Martin-Loeches   +7 more
doaj   +1 more source

Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization [PDF]

, 2016
Leukocyte migration across the blood barrier and into tissues represents a key process in the pathogenesis of inflammatory bowel diseases. The urokinase receptor (urokinase-type plasminogen activator receptor) is a master regulator of leukocyte ...
Fonteyne, Philippe, GRIECO, PAOLO, Genua, Marco, A. Malesci, Piontini, Andrea, P. Grieco, S. Danese, MERLINO, FRANCESCO, Ingangi, Vincenzo, M. Genua, Danese, Silvio, M. V. Carriero, YOUSIF, ALI MUNAIM, A. Piontini, F. Merlino, P. Fonteyne, V. Ingangi, A. M. Yousif, Carriero, Maria V, Malesci, Alberto, Fonteyne P, Malesci A, Piontini A, Genua M, Danese S, Yousif AM, Merlino F, Grieco P, Ingangi V, Carriero MV   +29 more
core   +1 more source

Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Mediate Human Stem Cell Tropism to Malignant Solid Tumors

Stem Cells, 2008
Abstract Human neural and mesenchymal stem cells have been identified for cell-based therapies in regenerative medicine and as vehicles for delivering therapeutic agents to areas of injury and tumors. However, the signals required for homing and recruitment of stem cells to these sites are not well understood.
Margarita, Gutova, Joseph, Najbauer, Richard T, Frank, Stephen Edward, Kendall, Anna, Gevorgyan, Marianne Z, Metz, Mark, Guevorkian, Marissa, Edmiston, Donghong, Zhao, Carlotta A, Glackin, Seung U, Kim, Karen S, Aboody   +11 more
openaire   +2 more sources

Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque

, 2012
Recently, plasma soluble urokinase plasminogen activator receptor (suPAR) has gained interest as a marker of cardiovascular risk. suPAR is released through the cleavage of urokinase plasminogen activator receptor (uPAR), which is found in monocytes ...
Grönberg, Caitriona,, Persson, Margaretha,, Edsfeldt, Andreas,, Nitulescu, Mihaela,, Nilsson, Marie MN,, Björkbacka, Harry,, Grufman, Helena,, Persson, Ana,, Goncalves, Isabel,, Lund University.   +9 more
core   +2 more sources

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Neoplasia: An International Journal for Oncology Research, 2009
Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players.
Peter Büchler, Howard A. Reber, James S. Tomlinson, Oliver Hankinson, Georgis Kallifatidis, Helmut Friess, Ingrid Herr, Oscar J. Hines   +7 more
doaj   +1 more source

Dattabase Information from Structure-based design of an urokinase-type plasminogen activator receptor–derived peptide inhibiting cell migration and lung metastasis

, 2009
Dattabase Information from Structure-based design of an urokinase-type plasminogen activator receptor–derived peptide inhibiting cell migration and lung ...
Mario De Rosa (15040481), Liliana Lista (2709868), Giuseppina Votta (2141533), Maria Vincenza Carriero (8713431), Renato Franco (184143), Maria Teresa Masucci (15040478), Maria Patrizia Stoppelli (133653), Katia Bifulco (133627), Vincenzo Pavone (133641), Claudio Arra (133331), Antonio Barbieri (458558), Immacolata Longanesi-Cattani (133632), Ornella Maglio (4379920)   +12 more
core   +1 more source

Pathogenic and Regulatory Roles of Fibrinolytic Factors in Autoimmune Diseases

Current Issues in Molecular Biology
Autoimmune diseases arise from complex interactions of genetic, environmental, and hormonal factors, yet their precise causes remain elusive. Beyond its canonical role in fibrin degradation, the fibrinolytic system is increasingly recognized as both a ...
Yosuke Kanno
doaj   +1 more source

Establishment of human patient-derived endometrial cancer xenografts in NOD scid gamma mice for the study of invasion and metastasis.

PLoS ONE, 2014
ObjectiveMost endometrial cancers are detected early and have a good prognosis, while some endometrial cancers are highly invasive, metastasize early, and respond suboptimally to therapy.
Kenji Unno, Masanori Ono, Abigail D Winder, Kruti P Maniar, Ajit S Paintal, Yanni Yu, Jian-Jun Wei, John R Lurain, J Julie Kim   +8 more
doaj   +1 more source