Results 81 to 90 of about 1,484,561 (230)

E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects

JCI Insight, 2021
Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality. We recently demonstrated that the C-terminal domain of endostatin, known as E4, prevented and reversed both ...
Shailza Sharma, Tomoya Watanabe, Tetsuya Nishimoto, Takahisa Takihara, Logan Mlakar, Xinh-Xinh Nguyen, Matthew Sanderson, Yunyun Su, Roger A. Chambers, Carol Feghali-Bostwick   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, Volume 20, Issue 11, Page 2955-2973, November 2026.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Serum Soluble Urokinase Plasminogen Activator Receptor Levels in Resistant Hypertension

Turkish Journal of Nephrology
Background: Although the precise pathogenetic mechanisms remain incompletely elucidated, hypertension is characterized by endothelial damage and inflammation. The soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker that
Nergiz Bayrakcı, Gülsüm Özkan, Sonat Pınar Kara, Ahsen Yılmaz, Aliye Çelikkol   +4 more
doaj   +3 more sources

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

BMC Ophthalmology, 2012
Background Corneal ulceration leading to perforation is associated with infectious and non-infectious destructive conditions in the cornea. The fibrinolytic (plasminogen/plasmin) system is considered to contribute to tissue remodeling in the wound ...
Sugioka Koji, Kodama Aya, Yoshida Koji, Okada Kiyotaka, Fukuda Masahiko, Shimomura Yoshikazu   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, Volume 20, Issue 11, Page 2569-2583, November 2026.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Soluble urokinase-type plasminogen activator receptor as a prognostic biomarker in critically ill patients.

, 2014
The aim of this study was to assess the role of blood soluble urokinase-type plasminogen activator receptor (suPAR) levels in the diagnosis and prognostication of sepsis in critically ill patients.Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics ...
Scolletta, Sabino, Taccone, Fabio Silvio, Santonocito, Cristina, Cortés, Diego Orbegozo, Vincent, Jean-Louis, Vincent, Jean Louis, Covajes, Cecilia, Taccone, Fabio, Gottin, Leonardo, Grazulyte, Daiva, Donadello, Katia, Scolletta S, Santonocito C, Cortes DO, Grazulyte D, Covajes C, Vincent JL, Taccone FS, Cortes D. O., Grazulyte D., Covajes C., Taccone F. S., Santonocito C., Donadello K., Vincent J. -L., Gottin L., Scolletta S.   +26 more
core   +1 more source

Early Acupuncture Following Thrombolysis in Acute Ischemic Stroke: A Meta‐Analysis of Randomized Controlled Trials on Efficacy and Safety

Brain and Behavior, Volume 16, Issue 11, November 2026.
This meta‐analysis included 10 randomized controlled trials involving 1,116 patients with acute ischemic stroke. Compared with thrombolysis plus standard care, adjunctive acupuncture was associated with reduced neurological deficits (NIHSS: MD = −2.90), improved daily living function (Barthel Index: MD = 12.07), and higher clinical response rates (RR =
Geng Li, Yihao Zhou, Zhe He, Shuai Li, Qichen Bai, Shuochen Fan, Xu Chen, Mengqi Yue, Xiaolin Yang, Jing Shi   +9 more
wiley   +1 more source

CHI3L1 on fibrinolytic system imbalance in chronic rhinosinusitis with nasal polyp

Frontiers in Immunology
BackgroundChronic rhinosinusitis (CRS) is an inflammatory disease affecting more than 10% of the global adult population. It is classified into Th1, Th2, and Th17 endotypes and eosinophilic and non-eosinophilic types.
Hyun-Woo Yang, Joo-Hoo Park, Jae-Min Shin, Hyeong-Guk Son, Hyeong-Guk Son, Tae-Hoon Kim, Seung-Hoon Lee, Il-Ho Park, Il-Ho Park, Il-Ho Park   +9 more
doaj   +1 more source

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

Frontiers in Oncology, 2018
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes.
Niaz Mahmood, Catalin Mihalcioiu, Shafaat A. Rabbani, Shafaat A. Rabbani   +3 more
doaj   +1 more source

The Plasma Proteome Mediates the Association Between Workplace Noise Exposure and Psychiatric Disorder Risk

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Workplace noise exposure was associated with adverse psychiatric outcomes and plasma proteomic alterations in the UK Biobank. Circulating proteins partially mediated associations with anxiety disorder and major depressive disorder (MDD), while workplace noise‐related protein risk scores provided proteomics‐based measures of individual susceptibility to
Xuan Zhao, Yan Fu, Dan‐Dan Zhang, Wei Xu, Hui‐Fu Wang, Wei Zhang, Jin‐Tai Yu, Lan Tan   +7 more
wiley   +1 more source