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Integrin α5β1 mediates the inhibitory effects of vasoinhibin on angiogenesis and vascular permeability. [PDF]
J Biol ChemZamora M +3 more
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The Urokinase Receptor Interactome
Current Pharmaceutical Design, 2011The urokinase receptor (uPAR) was originally identified as the membrane receptor of the serine protease urokinase (uPA), thereby implicated in the plasminogen activation cascade and regulation of pericellular proteolysis. Later on, vitronectin was showed to be another major ligand providing uPAR with a role in cell adhesion.
Gabriele, Eden +4 more
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The urokinase/urokinase-receptor system and cancer invasion.
Bailliere's clinical haematology, 1995u-PA binds with high affinity to its specific GPI-anchored receptor on the cell surface. The binding has at least two important consequences: (1) it enhances the rate of plasminogen activation on the cell surface; and (2) it focuses the u-PA proteolytic activity at the leading front of migrating cells. Several recent findings suggest that surface-bound
CONESE, MASSIMO, F. Blasi
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Urokinase Receptor and Integrin Interactions
Current Pharmaceutical Design, 2003Urokinase receptors (uPAR) were initially thought to function simply as a mechanism to concentrate the urokinase/plasmin system toward the cell surface. However, extensive evidence has accumulated that this glycolipid-anchored receptor also functions in both the adhesive and signaling pathways of many migratory cells. Mechanisms by which uPAR exercises
Matthias C, Kugler +2 more
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Urokinase receptors in human monocytes
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1990Receptors for the 54 kDa plasminogen activator urokinase were characterized in freshly isolated and 5-14 day cultured human monocytes. The half saturation constant was about 55 pM in freshly isolated monocytes at 4 degrees C and 140 pM at 37 degrees C.
Nykjaer, A +4 more
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The kringle stabilizes urokinase binding to the urokinase receptor
Blood, 2003AbstractThe structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (ΔK-scuPA) bound to soluble uPAR (suPAR) with the similar “on-rate” but ...
Khalil, Bdeir +7 more
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The receptor for urokinase‐plasminogen activator
Journal of Cellular Biochemistry, 1986AbstractMany human cells and cell lines possess a specific receptor that binds urokinase plasminogen activator (uPA) with an affinity of about 10−10 M. Bound enzyme is not internalized, is slowly dissociated, and retains its enzymatic activity. The amino acid sequence of uPA responsible for receptor binding is located within the first 35 aminoterminal ...
Francesco Blasi +2 more
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Lysis of Plasma Clots by Urokinase-Soluble Urokinase Receptor Complexes
Blood, 1998AbstractSingle-chain urokinase plasminogen activator (scuPA), the unique form secreted by cells, expresses little intrinsic plasminogen activator activity. scuPA can be activated by proteolytic cleavage to form a two-chain enzyme (tcuPA), which is susceptible to inhibition by plasminogen activator inhibitor type I (PAI-1).
A A, Higazi +6 more
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