Results 51 to 60 of about 1,378,916 (231)

The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. [PDF]

PLoS Pathogens, 2009
The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated.
Joppe W R Hovius, Maarten F Bijlsma, Gerritje J W van der Windt, W Joost Wiersinga, Bastiaan J D Boukens, Jeroen Coumou, Anneke Oei, Regina de Beer, Alex F de Vos, Cornelis van 't Veer, Alje P van Dam, Penghua Wang, Erol Fikrig, Marcel M Levi, Joris J T H Roelofs, Tom van der Poll   +15 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

Communications Biology, 2021
Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans.
Joseph Dowsett, Egil Ferkingstad, Line Jee Hartmann Rasmussen, Lise Wegner Thørner, Magnús K. Magnússon, Karen Sugden, Gudmar Thorleifsson, Mike Frigge, Kristoffer Sølvsten Burgdorf, Sisse Rye Ostrowski, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Thomas Folkmann Hansen, Karina Banasik, Søren Brunak, DBDS Genomic Consortium, Vinicius Tragante, Sigrun Helga Lund, Lilja Stefansdottir, Bjarni Gunnarson, Richie Poulton, Louise Arseneault, Avshalom Caspi, Terrie E. Moffitt, Daníel Gudbjartsson, Jesper Eugen-Olsen, Hreinn Stefánsson, Kári Stefánsson, Henrik Ullum   +29 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells

Biomarker Insights, 2017
The urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for various malignancies. The aim of this study is to assess the prognostic value of uPAR expression in neoplastic and stromal cells of patients with ...
Susanna WL de Geus, Victor M Baart, Martin C Boonstra, Peter JK Kuppen, Hendrica AJM Prevoo, Andrew P Mazar, Bert A Bonsing, Hans Morreau, Cornelis JH van de Velde, Alexander L Vahrmeijer, Cornelis FM Sier   +10 more
doaj   +1 more source

Prognostic effects of SuPAR and Neopterin Levels on Patients with Lung Cancer

Pteridines, 2020
Background: Two unique biomarkers, soluble form of the urokinase-type plasminogen activator receptor (suPAR) and neopterin, play a crucial role in inflammatory processes.
Yalcin Selim, Demir Mehmet Emin, Ozturk Reyhan, Kılınç Aytün Şadan, Suer Hatice, Karahan Irfan   +5 more
doaj   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Portelli, Michael A., Hall, Ian P., Sayers, Ian   +2 more
core  

Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. [PDF]

PLoS ONE, 2011
BACKGROUND: The cellular and molecular mechanisms of tumour response following chemotherapy are largely unknown. We found that low dose anti-tumour agents up-regulate early growth response 1 (EGR1) expression. EGR1 is a member of the immediate-early gene
Yukihiro Matsunoshita, Kosei Ijiri, Yasuhiro Ishidou, Satoshi Nagano, Takuya Yamamoto, Hiroko Nagao, Setsuro Komiya, Takao Setoguchi   +7 more
doaj   +1 more source

The urokinase/urokinase receptor system in mast cells: effects of its functional interaction with fmlf receptors

Translational medicine @ UniSa, 2016
Mast cell and basophils express the high affinity receptor for IgE (FcRI) and are primary effector cells of allergic disorders. The urokinase (uPA)-mediated plasminogen activation system is involved in physiological and pathological events based on cell migration and tissue remodelling, such as inflammation, wound healing, angiogenesis and metastasis.
ROSSI, FRANCESCA WANDA, PREVETE, Nella, Rivellese, Felice, Napolitano, Filomena, MONTUORI, NUNZIA, POSTIGLIONE, LOREDANA, Selleri, Carmine, DE PAULIS, AMATO   +7 more
openaire   +6 more sources