Results 31 to 40 of about 27,231 (235)

Involvement of Urokinase-Type Plasminogen Activator Receptor in the Formation of a Profibrotic Microenvironment in the Epicardial Region

Общая реаниматология, 2021
The study of the mechanisms of development and progression of fibrosis is one of the key directions of modern cardiology. Our work suggests that the urokinase receptor (uPAR) is involved in the regulation of mesothelial cell activity and epicardial ...
K. V. Dergilev, Z. I. Tsokolayeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuyev, B. N. Kulbitsky, E. V. Parfenova   +6 more
doaj   +1 more source

Urokinase Regulates Vitronectin Binding by Controlling Urokinase Receptor Oligomerization [PDF]

Journal of Biological Chemistry, 2002
Adhesion of monocytes to the extracellular matrix is mediated by a direct high affinity interaction between cell-surface urokinase-type plasminogen activator (uPA) receptor (uPAR) and the extracellular matrix protein vitronectin. We demonstrate a tight connection between uPA-regulated uPAR oligomerization and high affinity binding to immobilized ...
N. SIDENIUS, A. ANDOLFO, FESCE, RICCARDO GIUSEPPE, F. BLASI   +3 more
openaire   +4 more sources

suPAR, a Circulating Kidney Disease Factor

Frontiers in Medicine, 2021
Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation.
Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser   +3 more
doaj   +1 more source

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Düzce Tıp Fakültesi Dergisi, 2021
Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt, Engin Şebin, Sibel İba Yılmaz, Ali Batur, Orhan Delice, Omer Karasahin, Kadir Küçükceran   +6 more
doaj   +1 more source

Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]

, 2003
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Fuchs, T., Allgayer, H.
core   +1 more source

A Region in Domain II of the Urokinase Receptor Required for Urokinase Binding [PDF]

Journal of Biological Chemistry, 2000
The urokinase receptor is composed of three homologous domains based on disulfide spacing. The contribution of each domain to the binding and activation of single chain urokinase (scuPA) remains poorly understood. In the present paper we examined the role of domain II (DII) in these processes.
K, Bdeir, A, Kuo, A, Mazar, B S, Sachais, W, Xiao, S, Gawlak, S, Harris, A A, Higazi, D B, Cines   +8 more
openaire   +2 more sources

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

, 2011
Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Paul J. Declerck, Rehberg, Markus, Daniel Puhr-Westerheide, Lerchenberger, Max, Uhl, Bernd, Kanse, Sandip, Johanna Liebl, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Zahler, Stefan, Lorenzl, Stefan, Elisabeth Deindl, Khandoga, Andrej, Declerck, Paul J., Stefan Zahler, Schmalix, Wolfgang, Fritz Krombach, Liebl, Johanna, Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Andrej Khandoga, Stefan Lorenzl, Deindl, Elisabeth, Wolfgang Schmalix, Puhr-Westerheide, Daniel, Sandip Kanse   +27 more
core   +1 more source

Regulation of Urokinase/Urokinase Receptor Interaction by Heparin-like Glycosaminoglycans [PDF]

Journal of Biological Chemistry, 2001
We show here that the interaction between the urokinase-type plasminogen activator and its receptor, which plays a critical role in cell invasion, is regulated by heparan sulfate present on the cell surface and in the extracellular matrix. Heparan sulfate oligomers showing a composition close to the dimeric repeats of heparin (glucosamine-NSO(3)(6-OSO ...
PUCCI, MARCO, FIBBI, GABRIELLA, MAGNELLI, LUCIA, DEL ROSSO, MARIO   +3 more
openaire   +4 more sources

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes [PDF]

, 2012
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes.
Sato, Sumito, Soelch, Susanne, Luther, Thomas, Schmitt, Manfred, Baretton, Gustavo, Grismayer, Bettina, Kopitz, Charlotte, Krueger, Achim, Kotzsch, Matthias, Ries, Christian, Magdolen, Viktor   +10 more
core   +1 more source

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Kellermann, Josef, Wilhelm, Olaf G., Riemer, Christoph, Bürgle, Markus, Schroeck, Florian, Schmitt, Manfred, Kessler, Horst, Degitz, Klaus, Arroyo de Prada, Nuria, Schmiedeberg, Niko, Magdolen, Viktor   +10 more
core   +1 more source