Results 11 to 20 of about 27,231 (235)

Urokinase receptor and resistance to targeted anticancer agents. [PDF]

Front Pharmacol, 2015
The urokinase receptor (uPAR) is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell. In normal tissues, uPAR gene expression is limited; however, in cancer, uPAR is frequently over-expressed and ...
Gonias SL, Hu J.
europepmc   +9 more sources

Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene (Plaur) and Its Molecular Target Mef2d. [PDF]

Front Mol Neurosci, 2022
Urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored receptor of urokinase (uPA), which is involved in brain development, nerve regeneration, wound healing and tissue remodeling. We have recently shown that Plaur, which encodes uPAR,
Rysenkova KD, Troyanovskiy KE, Klimovich PS, Bulyakova TR, Shelomentseva EM, Shmakova AA, Tanygina DY, Ivashkina OI, Anokhin KV, Karagyaur MN, Zvereva MI, Rubina KA, Tkachuk VA, Semina EV.   +13 more
europepmc   +2 more sources

Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View. [PDF]

Front Cell Dev Biol, 2022
Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum ...
Alfano D, Franco P, Stoppelli MP.
europepmc   +2 more sources

The urokinase receptor and the regulation of cell proliferation

Thrombosis and Haemostasis, 2005
The urokinase receptor is a multifunctional receptor modulating both proteolytic dependent and independent processes. It binds the extracellular proteolytic enzyme urokinase and engages lateral interactions with several transmembrane receptors, including
Roberta Mazzieri, Blasi, F, Francesco Blasi, Mazzieri, R   +3 more
core   +6 more sources

Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin-treated breast cancer patients: a prospective exploratory study

Cardio-Oncology
Background Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established ...
Ruta Rao, Steven B. Feinstein, Lydia Usha, Jochen Reiser, Jian Chu, Kathrin Banach, Tochukwu M. Okwuosa, Changli Wei, Lillian Tung, Issam Atallah, Melody Cobleigh   +10 more
core   +2 more sources

TLR4 Response to LPS Is Reinforced by Urokinase Receptor. [PDF]

Front Immunol, 2020
GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood.
Kiyan Y, Tkachuk S, Rong S, Gorrasi A, Ragno P, Dumler I, Haller H, Shushakova N.   +7 more
europepmc   +2 more sources

Data on the inhibition of cell proliferation and invasion by the D2A-Ala peptide derived from the urokinase receptor. [PDF]

Data Brief, 2019
The data presented in this article are connected to our research article entitled “D2A-Ala peptide derived from the urokinase receptor exerts anti-tumoural effects in vitro and in vivo” (Furlan et al., 2018).
Furlan F, Eden G, Archinti M, Arnaudova R, Andreotti G, Citro V, Cubellis MV, Motta A, Degryse B.   +8 more
europepmc   +2 more sources

Soluble Urokinase Receptor and Liver Disease. [PDF]

Clin Liver Dis (Hoboken), 2019
Wei C, Zhu K, Reiser J.
europepmc   +4 more sources

The urokinase receptor: a ligand or a receptor? Story of a sociable molecule.

Cellular and Molecular Life Sciences, 2006
SUMMARY In this last decade, structure and functions of the receptor for the urokinase-type plasminogen activator have been extensively studied and characterized.
RAGNO, Pia
core   +5 more sources

Urokinase-type plasminogen activator receptor as a predictive marker for cardiac disease among type 2 diabetic patients

Medical Journal of Babylon, 2023
Background: Type 2 diabetes mellitus is a progressive and chronic disease manifested by β-cell dysfunction and improved insulin resistance. Higher levels of urokinase-type plasminogen activator receptors have been found to predict morbidity and mortality
Melak Saleh Mohammed, Hind Shakir Ahmed
doaj   +1 more source