Results 21 to 30 of about 27,231 (235)

Immune Activation Mediates the Association of Advanced Hepatic Fibrosis With Adverse Outcomes in Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Literature suggests a bidirectional association between advanced hepatic fibrosis (AHF) and coronary artery disease (CAD). We evaluated the association of AHF with immune activation, systemic inflammation, and adverse outcomes in patients with
Vardhmaan Jain, Anurag Mehta, Terence B. Lee, Chang Liu, Nicholas W. S. Chew, Yi‐An Ko, Matthew E. Gold, Daniel A. Gold, Nishant Vatsa, Shivang R. Desai, Jonathan H. Kim, Alireza Rahbar, Yazan Haroun, Kiran Ejaz, Salim S. Hayek, Mohammad S. Siddiqui, Fadi N. Salloum, Laurence S. Sperling, Arun J. Sanyal, Arshed A. Quyyumi   +19 more
doaj   +1 more source

Exogenous Urokinase Inhibits Proteasomal Degradation of Its Cognate Urokinase Plasminogen Activator Receptor

Frontiers in Pharmacology, 2022
Acute pulmonary embolism (APE) is a debilitating condition with high incidence and mortality rates. APE is widely treated with the serine protease urokinase or urokinase-type plasminogen activator (uPA) that functions by resolving blood clots via ...
Ran Zhu, Ting-Wei Liu, Fan Liu
doaj   +1 more source

Soluble urokinase receptor is a kidney-specific vasoconstrictor. [PDF]

EBioMedicine
Summary: Background: Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune system-derived risk factor for acute and chronic kidney diseases.
Rasmussen SB, Lindhardt RB, Gyarmati G, Madsen K, Bistrup C, Lund L, Ostrowski SR, Wei C, Peti-Peterdi J, Svenningsen P, Reiser J, Ravn HB.   +11 more
europepmc   +2 more sources

Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR. [PDF]

Data Brief, 2017
The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and ...
Degryse B, Britto M, Shan CX, Wallace RG, Rochfort KD, Cummins PM, Meade G, Murphy RP.   +7 more
europepmc   +2 more sources

SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung

eLife, 2021
Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance.
Alan E Mast, Alisa S Wolberg, David Gailani, Michael R Garvin, Christiane Alvarez, J Izaak Miller, Bruce Aronow, Daniel Jacobson   +7 more
doaj   +1 more source

Thrombo-inflammatory biomarkers to predict sepsis outcome

International Journal of Immunopathology and Pharmacology, 2021
Background: Sepsis has been redefined recently as life-threatening organ dysfunction caused by dysregulated host responses to infection and septic shock. Soluble urokinase plasminogen activator receptor (SuPAR) and plasminogen activator inhibitor-1(PAI-1)
Alaa Efat, Sabry Abdallah Shoeib, Ayman F Arafa, Ashraf Abdelraof Dawod, Mohamad A Abd ElHafez, Essam A Abd ElMohsen, Hany F Eladly, Reda A Ibrahim, Aly Elkholy   +8 more
doaj   +1 more source

Transcriptome Sequencing Identifies PLAUR as an Important Player in Patients With Dermatomyositis-Associated Interstitial Lung Disease

Frontiers in Genetics, 2021
Dermatomyositis (DM), an inflammatory disorder, is often associated with interstitial lung disease (ILD). However, the underlying mechanism remains unclear.
Juan Chen, Ruixian Zhang, Min Xie, Chunyan Luan, Xiaolan Li   +4 more
doaj   +1 more source

Values of serum PCT, suPAR combined with severity scores for evaluating prognosis of septic shock patients

Romanian Journal of Laboratory Medicine, 2021
Background: To explore the values of serum procalcitonin (PCT), soluble urokinase-type plasminogen activator receptor (suPAR) combined with APACHE II and SOFA scores for evaluating the prognosis of septic shock patients.
Wang Wenxin, Jie Yingxin, Zhou Jia
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Crystal structure and cellular functions of uPAR dimer

Nature Communications, 2022
The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Yingping Cao, Liqing Chen, Longguang Jiang, Cai Yuan, Mingdong Huang   +9 more
doaj   +1 more source