Results 41 to 50 of about 1,378,916 (231)

Predicting Mortality in African Americans With Type 2 Diabetes Mellitus: Soluble Urokinase Plasminogen Activator Receptor, Coronary Artery Calcium, and High‐Sensitivity C‐Reactive Protein

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundType 2 diabetes mellitus is a major risk factor for cardiovascular disease; however, outcomes in individual patients vary. Soluble urokinase plasminogen activator receptor (suPAR) is a bone marrow–derived signaling molecule associated with ...
Salim S. Hayek, Jasmin Divers, Mohamad Raad, Jianzhao Xu, Donald W. Bowden, Melissa Tracy, Jochen Reiser, Barry I. Freedman   +7 more
doaj   +1 more source

Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization [PDF]

, 2016
Leukocyte migration across the blood barrier and into tissues represents a key process in the pathogenesis of inflammatory bowel diseases. The urokinase receptor (urokinase-type plasminogen activator receptor) is a master regulator of leukocyte ...
Fonteyne, Philippe, GRIECO, PAOLO, Genua, Marco, A. Malesci, Piontini, Andrea, P. Grieco, S. Danese, MERLINO, FRANCESCO, Ingangi, Vincenzo, M. Genua, Danese, Silvio, M. V. Carriero, YOUSIF, ALI MUNAIM, A. Piontini, F. Merlino, P. Fonteyne, V. Ingangi, A. M. Yousif, Carriero, Maria V, Malesci, Alberto, Fonteyne P, Malesci A, Piontini A, Genua M, Danese S, Yousif AM, Merlino F, Grieco P, Ingangi V, Carriero MV   +29 more
core   +1 more source

Changes in levels of urokinase receptor and other components of fibrinolytic system in brain tissues in urokinase gene-knockout mice with B16/F10 melanoma growing together with chronic neurogenic pain

Исследования и практика в медицине, 2022
Purpose of the study. An analysis of the changes in components of the urokinase system in the brain of urokinase gene-knockout mice (uPA-/-) with B16/F10 melanoma growing alone and together with chronic neurogenic pain (CNP).Materials and methods.
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, N. D. Cheryarina, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. A. Nemashkalova   +7 more
doaj   +1 more source

The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis

Frontiers in Immunology, 2022
Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou, Ming-Li Zou, Ying-Ying Teng, Zhong-hua Chen, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Jun-Jie Wu, Zheng-Dong Yuan, Xiao-Yu Tang, Shun Yu, Jun-Xing Ye, Xia Li, Xiao-Jin Zhou, Feng-Lai Yuan, Feng-Lai Yuan   +15 more
doaj   +1 more source

Fibrinolytics: from the thrombolysis to the processes of blood vessels growth and remodeling, neurogenesis, carcinogenesis and fibrosis [PDF]

Терапевтический архив, 2019
One of the most outstanding scientific achievements in the thrombolysis is the development and administration of fibrinolysin - the first Soviet drug that lyses blood clots.
V A Tkachuk, Ye V Parfyonova, O S Plekhanova, V V Stepanova, M Yu Menshikov, E V Semina, R Sh Bibilashvili, E I Chazov   +7 more
doaj   +1 more source

Urokinase-type plasminogen activator is a modulator of synaptic plasticity in the central nervous system: implications for neurorepair in the ischemic brain

Neural Regeneration Research, 2020
The last two decades have witnessed a rapid decrease in mortality due to acute cerebral ischemia that paradoxically has led to a rapid increase in the number of patients that survive an acute ischemic stroke with various degrees of disability ...
Manuel Yepes
doaj   +1 more source

Evaluation of Urokinase Plasminogen Activator Receptor, Soluble Urokinase Plasminogen Activator Receptor, and β1 Integrin in Patients with Hodgkin′s Lymphoma

Advanced Biomedical Research, 2017
Background: The objective of this study is to indicate the role of urokinase plasminogen activator receptor (uPAR), soluble uPAR (suPAR), and β1 integrin in tumor growth and invasion of lymph nodes from Hodgkin's lymphoma (HL) patients.
Shirin Kouhpayeh, Alireza Andalib, Marjan Gharagozloo, Mohammad Hossein Sanei, Nafiseh Esmaeil, Mohammad Reza Maracy   +5 more
doaj   +1 more source

Augmented Urokinase Receptor Expression in Atheroma [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1995
Abstract Smooth muscle cell proliferation and migration into neointima are hallmarks of atherogenesis. However, mechanisms responsible have not yet been fully elucidated. One potential mediator of both smooth muscle cell proliferation and migration is activation of plasminogen by activators bound to receptors on cells within ...
H, Noda-Heiny, A, Daugherty, B E, Sobel
openaire   +2 more sources

Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin-treated breast cancer patients: a prospective exploratory study

Cardio-Oncology
Background Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established ...
Jian Chu, Lillian Tung, Issam Atallah, Changli Wei, Melody Cobleigh, Ruta Rao, Steven B. Feinstein, Lydia Usha, Kathrin Banach, Jochen Reiser, Tochukwu M. Okwuosa   +10 more
doaj   +1 more source

New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms

Cells, 2020
The urokinase (uPA) receptor (uPAR) plays a key role in cell migration. We previously showed that uPAR-negative HEK-293 cells efficiently migrate toward serum but, after uPAR ectopic expression, migrate only in a uPAR-dependent manner. In fact, migration
Anna Gorrasi, Anna Maria Petrone, Anna Li Santi, Mariaevelina Alfieri, Nunzia Montuori, Pia Ragno   +5 more
doaj   +1 more source