Results 91 to 100 of about 3,771 (207)

The effects of urolithin A on poly I:C-induced microglial activation [PDF]

Frontiers in Cellular Neuroscience
Neuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a “cytokine storm” in the periphery that eventually leads to microglial activation in the brain.
Yakum Benard Mingo, Yakum Benard Mingo, Lea Gabele, Lea Gabele, Niklas Lonnemann, Bert Brône, Martin Korte, Martin Korte, Shirin Hosseini, Shirin Hosseini   +9 more
openaire   +4 more sources

Microbial method for reproducing the human urolithin metabotypes in vitro and in vivo

, 2022
The present invention relates to a new bacterial strain and a new urolithin named urolithin G. The new strain of the invention is Enterocloster bolteae CEBAS S4A9 DSM 34392 and can customize urolithin production to mimic metabotype A and metabotype B in ...
Beltrán Riquelme, David, Selma, María Victoria, Tomás Barberán, Francisco, García-Villalba, Rocío, Espín de Gea, Juan Carlos   +4 more
core  

Antioxidants in Plant‐Based Food Matrices: From Structure–Activity and Degradation Kinetics to Formulation Design

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 4, July 2026.
ABSTRACT Plant‐based antioxidants are widely incorporated into foods to retard oxidative deterioration and to deliver health‐related benefits. Yet, their in‐product and in vivo performance frequently diverges from predictions based on solution‐phase chemical assays, because matrix interactions, processing history, and host metabolism reshape both ...
Márcio Vargas‐Ramella, Carmen Silvia Favaro‐Trindade, Bárbara Miranda‐Vilela, Mariana Estefanuto‐Costa, Marina Franco‐Brito, Bibiana Alves dos Santos, Paulo Cezar Bastianello Campagnol   +6 more
wiley   +1 more source

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

, 2012
Numerous in vitro and in vivo studies indicate that ellagitannins exhibit anti-inflammatory, anti-atherosclerotic and anti-angiogenic activity which support their potential preventive effect against cardiovascular diseases.
Larrosa, Mar, Tomás Barberán, Francisco, Giménez-Bastida, J. A., González-Sarrías, Antonio, Espín de Gea, Juan Carlos, García-Conesa, María Teresa   +5 more
core   +1 more source

Ethnomedicinal Properties and Technological Challenges of Pomegranate Fruit as a Value‐Added Product

eFood, Volume 7, Issue 3, June 2026.
This review aims to provide a comprehensive review of pomegranate (Punica granatum) as a nourishing powerhouse, focusing on its remarkable nutritional conformation, bioactive composites, and substantial health assistance. This emphasizes the adaptableness and developing demand in the functional food market, as it discovers the potential solicitations ...
Muhammad Tayyab Arshad, Farhang Hameed Awlqadr, Sammra Maqsood, Hatem A. Al‐Aoh, Md. Sakhawot Hossain, Ali Ikram   +5 more
wiley   +1 more source

Induction of autophagy and activation of SIRT-1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and differentiated 3D human neural progenitor cells [PDF]

, 2019
Scope: Urolithin A is an anti-inflammatory and neuroprotective gut-derived metabolite from ellagitannins and ellagic acid in pomegranate, berries, and nuts. The roles of SIRT-1 and autophagy in the neuroprotective activity of urolithin A are investigated.
El-Bakoush, Abdelmeneim, Olajide, Olumayokun, Harsharan Bhatia, Katola, Folashade, Velagapudi, Ravikanth, El‐Bakoush, Abdelmeneim, Olumayokun A. Olajide, Ravikanth Velagapudi, Abdelmeneim El‐Bakoush, Bhatia, Harsharan, Lepiarz, Izabela, Fiebich, Bernd L., Bhatia, Harsharan S., Katola, Folashade O., Izabela Lepiarz, Folashade O. Katola, Bernd L. Fiebich, Olajide, Olumayokun A.   +17 more
core   +1 more source

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10−/− Mice [PDF]

, 2020
Human campylobacteriosis represents an infectious enteritis syndrome caused by Campylobacter species, mostly Campylobacter jejuni. Given that C. jejuni infections are rising worldwide and antibiotic treatment is usually not indicated, novel treatment ...
Mousavi, Soraya, Bereswill, Stefan, Heimesaat, Markus M., Weschka, Dennis   +3 more
core   +1 more source

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, Volume 3, Issue 2, Page 163-184, June 2026.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source