Results 171 to 180 of about 3,740 (205)

The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention

Current Cancer Drug Targets, 2022
Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the gastrointestinal tract than its parent substances. Thus, the variable effects of ellagitannin-reach food (like pomegranate fruit, walnuts, tea, and others) on people's health might be linked ...
Vladimir Rogovskii
exaly   +3 more sources

Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells

International Journal of Molecular Sciences, 2021
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic ...
Abdulaziz Musa Alzahrani, Mohammed Razeeth Shait Mohammed, Aftab Ahmad   +2 more
exaly   +2 more sources

Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects

Nutrients, 2023
Urolithin A (UA) is a naturally occurring compound derived from the metabolism of gut microbiota, which has attracted considerable research attention due to its pharmacological effects and potential implications in muscle health and performance.
He Qian, Chang Liu, Qian He
exaly   +2 more sources

Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in Caenorhabditis elegans

Journal of Agricultural and Food Chemistry, 2023
Urolithin, intestinal microbiota metabolites of ellagitannin-rich foods, exhibit anti-aging activities. However, urolithin A is significantly superior to other types of urolithin with regard to this anti-aging function.
Shumao Cui, Bingyong Mao, Qiuxiang Zhang   +2 more
exaly   +2 more sources

Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes

Journal of Agricultural and Food Chemistry
Streptococcus thermophilus FUA329 converts ellagic acid (EA) to urolithin A (Uro-A), which is not autonomously converted by the gut microbiota to produce highly bioavailable and multibiologically active Uro-A in urolithin metabotype 0 (UM-0) populations. We consider that Streptococcus thermophilus FUA329 has the potential to be developed as a probiotic.
Mengjie Xia, Ziyan Hua, Yaling Zhao, Gewen Zhang, Xiaoyue Hou, Guang Yang, Shu Liu, Yaowei Fang   +7 more
openaire   +3 more sources

The Synthesis of Urolithins and their Derivatives and the Modes of Antitumor Action

Mini-Reviews in Medicinal Chemistry, 2023
Abstract: Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7), which have been isolated by now.
Lei Yao, Xiangrong Xu, Zhuanhong Liu
openaire   +2 more sources

Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia

Phytomedicine, 2019
Background: Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs.
Jin-Sun Park, Hee-Sun Kim
exaly   +2 more sources

Gastrointestinal stability of urolithins: an in vitro approach

European Journal of Nutrition, 2015
Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
Mena P., Dall'Asta M., Calani L., Brighenti F., Del Rio D.   +4 more
openaire   +4 more sources

Urolithin B loaded in cerium oxide nanoparticles enhances the anti-glioblastoma effects of free urolithin B in vitro

Journal of Trace Elements in Medicine and Biology, 2023
Glioblastoma multiforme (GBM) is the most aggressive kind of malignant primary brain tumor in humans. Given the limitation of Conventional therapeutic strategy, the development of nanotechnology and natural product therapy seems to be an effective method enhancing the prognosis of GBM patients.
Ghasem Rahimi-Kalateh Shah Mohammad, Alireza Motavalizadehkakhky, Majid Darroudi, Rahele Zhiani, Jamshid Mehrzad, Amir R. Afshari   +5 more
openaire   +2 more sources

Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells

Journal of Agricultural and Food Chemistry, 2017
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang, Wei-Chia Chang, Chen Hsu, Nan-Wei Su   +3 more
openaire   +2 more sources