Results 201 to 210 of about 21,131,763 (241)

Urolithin A Nanoparticle Therapy for Cisplatin-Induced Acute Kidney Injury

Nephron, 2022
Cisplatin continues to be one of the frontline cytotoxic drugs. However, cisplatin-induced acute kidney injury (AKI) remains a major unmet medical need without any approved pharmacological interventions. The involvement of reactive oxygen species generation and activation of inflammatory and apoptotic pathways in the pathogenesis of cisplatin-induced ...
openaire   +2 more sources

Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial

Nutrients
Background: In healthy adults, probiotic supplementation alone does not increase Urolithin A (UroA) and rarely increases butyrate, both microbiome-derived metabolites that influence key biological functions involved in regulating gastrointestinal ...
Brooke A. Napier, J. Allegretti, P. Feuerstadt, Colleen R. Kelly, Nick W. Van Hise, R. Jäger, Z. Kassam, Gregor Reid   +7 more
semanticscholar   +1 more source

Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation.

ACS Chemical Neuroscience
Neuroinflammation is a key factor in age-related cognitive decline and memory impairment. UAS03, a potent synthetic analogue of Urolithin-A, has demonstrated anti-inflammatory and antioxidant properties.
Dipan Maity, Vikrant Rahi, Sandya Tambi Dorai, Sandeep Chandrashekharappa, R. Kaundal   +4 more
semanticscholar   +1 more source

The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells

Food and Chemical Toxicology, 2020
The promotion of senescence in cancer cells by dietary (poly)phenols gained attention as a promising chemopreventive strategy against colorectal (CRC) and other cancers. Urolithins (Uros) are ellagitannins and ellagic acid-derived gut microbiota metabolites that reach high concentrations in the human colon.
Juan Antonio, Giménez-Bastida, María Ángeles, Ávila-Gálvez, Juan Carlos, Espín, Antonio, González-Sarrías   +3 more
openaire   +2 more sources

Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing

Autophagy
Mitochondrial dysfunction and impaired mitophagy are hallmarks of ageing and age-related pathologies. Disrupted inter-organellar communication among mitochondria, endoplasmic reticulum (ER), and lysosomes, further contributes to cellular dysfunction ...
Antonis Roussos, Katerina Kitopoulou, Fivos Borbolis, Christina Ploumi, Despoina D. Gianniou, Zhiquan Li, Haijun He, Eleni Tsakiri, Helena Borland, I. Kostakis, M. Samiotaki, I. Trougakos, V. A. Bohr, Konstantinos Palikaras   +13 more
semanticscholar   +1 more source

Emerging evidence of Urolithin A in sports nutrition: bridging preclinical findings to athletic applications

Frontiers in Nutrition
Urolithin A (UA), a gut microbiota-derived metabolite of ellagic acid and ellagitannins, is emerging as a novel sports nutrition supplement with multifaceted benefits.
Manda Wang, Liang Yu
semanticscholar   +1 more source

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Science Translational Medicine, 2021
The mitophagy inducer urolithin A reverts muscular dystrophies.
Peiling Luan, Davide D’Amico, Pénélope A. Andreux, Pirkka-Pekka Laurila, Martin Wohlwend, Hao Li, Tanes Imamura de Lima, Nicolas Place, Chris Rinsch, Nadège Zanou, Johan Auwerx   +10 more
openaire   +2 more sources

Urolithin A causes p21 up-regulation in prostate cancer cells

European Journal of Nutrition, 2015
Walnuts contain several bioactive compounds, including pedunculagin, a polyphenol metabolized by microbiota to form urolithins, namely urolithin A (UA). The aim of this study was to determine gene expression changes in prostate cancer cells after incubation with UA.We performed a genomic analysis to study the effect of UA on LNCaP prostate cells. Cells
Claudia, Sánchez-González, Carlos J, Ciudad, Maria, Izquierdo-Pulido, Véronique, Noé   +3 more
openaire   +2 more sources

Differential effects of ellagic acid on non-alcoholic fatty liver disease in mice: grouped by urolithin A-producing capacity.

Food & Function
Ellagic acid (EA) exhibits protective effects on non-alcoholic fatty liver disease (NAFLD). However, the ability to produce urolithins and the health benefits associated with EA consumption differ considerably among individuals.
Fengping Li, Jinxin Luo, Qingzhuang Xie, Liangqian He, Wu Li, Ruili Yang, Meiying Li   +6 more
semanticscholar   +1 more source

Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy.

International Immunopharmacology
Radiation pneumonitis (RP) is a common and severe complication of radiotherapy, whose pathogenesis involves complex inflammatory responses and cellular damage. Despite its clinical significance, effective treatments remain limited. This study investigates the role of radiation-induced PINK1/PRKN-mediated mitophagy and type I interferon responses in RP ...
Anqi Zhang, Shilan Luo, Peng Li, Lu Meng, Litang Huang, Hongxia Cheng, Chenhui Zhao, Hongbin Tu, Xiaomei Gong   +8 more
semanticscholar   +3 more sources