Results 221 to 230 of about 21,131,763 (241)

Targeting aging with urolithin A in humans

Ageing Research Reviews
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic, Lim, Xuan K., Khoo, Anderson LY, Sandalova, Elena, Guan, Lihuan, Feng, Lei, Maier, Andrea B.   +6 more
openaire   +1 more source

Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.

ACS Nano
Severe acute pancreatitis (SAP), characterized by pancreatic acinar cell death, currently lacks effective targeted therapies. Ellagic acid (EA), rich in pomegranate, shows promising anti-inflammatory and antioxidant effects in SAP treatment. However, the
Hong-Xin Kang, Qian Hu, Yue Yang, Gaigai Huang, Juan Li, Xianlin Zhao, Lv Zhu, Hang Su, Wenfu Tang, Meihua Wan   +9 more
semanticscholar   +1 more source

Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes

Journal of Agricultural and Food Chemistry
Streptococcus thermophilus FUA329 converts ellagic acid (EA) to urolithin A (Uro-A), which is not autonomously converted by the gut microbiota to produce highly bioavailable and multibiologically active Uro-A in urolithin metabotype 0 (UM-0) populations. We consider that Streptococcus thermophilus FUA329 has the potential to be developed as a probiotic.
Mengjie Xia, Ziyan Hua, Yaling Zhao, Gewen Zhang, Xiaoyue Hou, Guang Yang, Shu Liu, Yaowei Fang   +7 more
openaire   +2 more sources

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Nature Medicine, 2016
D. Ryu, L. Mouchiroud, P. Andreux, E. Katsyuba, N. Moullan, Amandine A Nicolet-dit-Félix, Evan G. Williams, Pooja Jha, G. Lo Sasso, Damien Huzard, P. Aebischer, C. Sandi, C. Rinsch, J. Auwerx   +13 more
semanticscholar   +1 more source

Urolithin A, Mithochondrial Biogenesis, and Exercise Performance

ACSM'S Health & Fitness Journal, 2023
openaire   +1 more source

Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

Cell Reports Medicine
A. Akhtar, Md Shakir, Mohammad Sufyan Ansari, Divya, Md Imam Faizan, Varnit Chauhan, Aashi Singh, Ruquaiya Alam, Iqbal Azmi, Sheetal Sharma, Mehak Pracha, Insha Mohi Uddin, Uzma Bashir, Syeda Najidah Shahni, Rituparna Chaudhuri, Sarah Albogami, Rik Ganguly, Shakti Sagar, Vijay Pal Singh, G. Kharya, A. K. Srivastava, U. Mabalirajan, Soumya Sinha Roy, Irfan Rahman, Tanveer Ahmad   +24 more
semanticscholar   +1 more source

Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes

Journal of Molecular Neuroscience
Gengxin Lu, Junyu Wu, Zhihui Zheng, Zhezhi Deng, Xue Xu, Xintian Li, Xiaoqiu Liang, Weiwei Qi, Shifeng Zhang, Yuemin Qiu, Minping Li, Junjie Guo, Haiwei Huang   +12 more
semanticscholar   +1 more source

Tu1490 UROLITHIN A REGULATES INTESTINAL ENTEROCYTE DIFFERENTIATION

Gastroenterology
Chang Li, Yuning Zhou, Heidi L. Weiss, Qingding Wang, B. Mark Evers   +4 more
openaire   +1 more source

Mitopure™ (Proprietary Urolithin A) Bioavailability in Healthy Adults

Case Medical Research, 2019
openaire   +1 more source

Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury.

International Immunopharmacology
Kongbin Chen, Jiahao Ying, Jiangwei Zhu, Liang Chen, Rongjie Liu, Mengqi Jing, Yuchao Wang, Kailiang Zhou, Long Wu, Chenyu Wu, Jian Xiao, Wenfei Ni   +11 more
semanticscholar   +1 more source