Results 191 to 200 of about 2,467 (216)

Research progress of ellagitannin intestinal metabolite urolithins

China Journal of Chinese Materia Medica, 2016
Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins.
Ben-Hong, Zhou, Zhen-Peng, Qiu, Hui-Lan, Yi, Ding-Shan, Zhou, Jing, Wang, Yue, Wu   +5 more
openaire   +2 more sources

Urolithin A attenuates arsenic-induced gut barrier dysfunction

Archives of Toxicology, 2022
Environmental chemicals such as inorganic arsenic (iAs) significantly contribute to redox toxicity in the human body by enhancing oxidative stress. Imbalanced oxidative stress rapidly interferes with gut homeostasis and affects variety of cellular processes such as proliferation, apoptosis, and maintenance of intestinal barrier integrity.
Sweta Ghosh, Mayukh Banerjee, Bodduluri Haribabu, Venkatakrishna Rao Jala   +3 more
openaire   +2 more sources

Synthesis of urolithin derivatives and their anti-inflammatory activity

Biochemical and Biophysical Research Communications
Two series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li, Zhengzheng Zhang, Guangsen Xu, Zhiying Li, Chunhua Lu, Yuemao Shen   +5 more
openaire   +2 more sources

Appeal of Urolithins from Synthesis to Biological Activities

Journal of Agricultural and Food Chemistry
Urolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
openaire   +2 more sources

Targeting aging with urolithin A in humans

Ageing Research Reviews
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic, Lim, Xuan K., Khoo, Anderson LY, Sandalova, Elena, Guan, Lihuan, Feng, Lei, Maier, Andrea B.   +6 more
openaire   +1 more source

Neuroprotective Attributes of Gut-derived Urolithins in Parkinson’s Disease

Molecular Neurobiology
Urolithins, a class of gut microbiota-derived metabolites, are produced from dietary ellagitannins and ellagic acid. Their pleiotropic activities, including antioxidant, anti-inflammatory, and mitophagy-enhancing effects, position them as promising candidates for Parkinson's disease (PD), a disorder increasingly understood through the lens of gut-brain
Sushila, Chhetry, Abhideep, Roy, Rubina, Roy, Pallab, Bhattacharya, Victor, Tapias, Anupom, Borah   +5 more
openaire   +2 more sources

Neuroprotective effects of urolithin a in a mouse model of intracerebral hemorrhage

Neuropharmacology
Intracerebral hemorrhage (ICH) accounts for 10-15 % of all stroke cases and is associated with high mortality and morbidity. Brain injury caused by ICH includes primary and secondary brain injury. Neuroinflammation and apoptosis play important roles in the pathological process of secondary brain injury after ICH.
Yan Guo, Xiangyu Zhang, Jianzhong Deng, Qiuyang Su, Yuanyuan Liu, Gaili Yan, Sara Xue, V. Wee Yong, Mengzhou Xue   +8 more
openaire   +2 more sources

Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes

Journal of Agricultural and Food Chemistry
Streptococcus thermophilus FUA329 converts ellagic acid (EA) to urolithin A (Uro-A), which is not autonomously converted by the gut microbiota to produce highly bioavailable and multibiologically active Uro-A in urolithin metabotype 0 (UM-0) populations. We consider that Streptococcus thermophilus FUA329 has the potential to be developed as a probiotic.
Mengjie Xia, Ziyan Hua, Yaling Zhao, Gewen Zhang, Xiaoyue Hou, Guang Yang, Shu Liu, Yaowei Fang   +7 more
openaire   +2 more sources

Urolithins: a Comprehensive Update on their Metabolism, Bioactivity, and Associated Gut Microbiota

Molecular Nutrition and Food Research, 2022
Rocio Garcia Villalba, J A Giménez-Bastida, Adrián Cortés Martín   +2 more
exaly  

Ellagic Acid and Urolithins A and B Differentially Regulate Fat Accumulation and Inflammation in 3T3-L1 Adipocytes While Not Affecting Adipogenesis and Insulin Sensitivity

International Journal of Molecular Sciences, 2020
Luis Cisneros-Zevallos
exaly