Results 181 to 190 of about 1,721 (201)
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The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
Current Cancer Drug Targets, 2022Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the gastrointestinal tract than its parent substances. Thus, the variable effects of ellagitannin-reach food (like pomegranate fruit, walnuts, tea, and others) on people's health might be linked ...
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Effect of Urolithin A on Bone Repair in Mice with Bone Defects
Tissue Engineering and Regenerative Medicine, 2021Bone defect difficult to manage clinically and it is a big challenge to repair it. Secondary metabolites source from herb has shown potential for the treatment of bone defect.Mesenchymal stem cells (MSCs) were isolated from mice and incubated with urolithin A (UA) (10, 25, and 50 µg/mL).
Jianmin, Liu +4 more
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Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins
Journal of Agricultural and Food Chemistry, 2010Pomegranate juice derived ellagitannins and their intestinal bacterial metabolites, urolithins, inhibited TCDD-induced CYP1-mediated EROD activity in vitro with IC(50) values ranging from 56.7 microM for urolithin A to 74.8 microM for urolithin C.
Sashi G Kasimsetty +2 more
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Urolithin A attenuates arsenic-induced gut barrier dysfunction
Archives of Toxicology, 2022Environmental chemicals such as inorganic arsenic (iAs) significantly contribute to redox toxicity in the human body by enhancing oxidative stress. Imbalanced oxidative stress rapidly interferes with gut homeostasis and affects variety of cellular processes such as proliferation, apoptosis, and maintenance of intestinal barrier integrity.
Sweta Ghosh +3 more
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Research progress of ellagitannin intestinal metabolite urolithins
China Journal of Chinese Materia Medica, 2016Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins.
Ben-Hong, Zhou +5 more
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Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2
International Journal of Food Sciences and Nutrition, 2017 Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to ...
Milica Kojadinovic +2 more
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Synthesis of urolithin derivatives and their anti-inflammatory activity
Biochemical and Biophysical Research CommunicationsTwo series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li +5 more
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Appeal of Urolithins from Synthesis to Biological Activities
Journal of Agricultural and Food ChemistryUrolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
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Targeting aging with urolithin A in humans
Ageing Research ReviewsUrolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic +6 more
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Neuroprotective Attributes of Gut-derived Urolithins in Parkinson’s Disease
Molecular NeurobiologyUrolithins, a class of gut microbiota-derived metabolites, are produced from dietary ellagitannins and ellagic acid. Their pleiotropic activities, including antioxidant, anti-inflammatory, and mitophagy-enhancing effects, position them as promising candidates for Parkinson's disease (PD), a disorder increasingly understood through the lens of gut-brain
Chhetry, Sushila +5 more
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