Results 171 to 180 of about 1,721 (201)

Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways

open access: yesJournal of Agricultural and Food Chemistry, 2018
Emerging data suggest that urolithins, gut microbiota metabolites of ellagitannins, contribute toward multiple health benefits attributed to ellagitannin-rich foods, including walnuts, red raspberry, strawberry, and pomegranate. However, there is limited
Jialin Xu, Hang Ma, Navindra P Seeram
exaly   +2 more sources

Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro

open access: yesNutritional Neuroscience, 2019
Objectives: Urolithins, ellagitannin-gut microbial-derived metabolites, have been reported to mediate pomegranate’s neuroprotective effects against Alzheimer’s disease (AD), but there are limited data on their effects against neuroinflammation.
Nicholas A Dasilva, Hang Ma, Aseel Eid
exaly   +2 more sources

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

open access: yesACS Chemical Neuroscience, 2016
Pomegranate shows neuroprotective effects against Alzheimer\u27s disease (AD) in several reported animal studies. However, whether its constituent ellagitannins and/or their physiologically relevant gut microbiota-derived metabolites, namely, urolithins (
Tao Yuan, Hang Ma, Weixi Liu
exaly   +3 more sources
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The Synthesis of Urolithins and their Derivatives and the Modes of Antitumor Action

Mini-Reviews in Medicinal Chemistry, 2023
Abstract: Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7), which have been isolated by now.
Lei Yao, Xiangrong Xu
exaly   +3 more sources

Ellagic Acid and Polyhydroxylated Urolithins Are Potent Catalytic Inhibitors of Human Topoisomerase II: An in Vitro Study

open access: yesJournal of Agricultural and Food Chemistry, 2012
Ellagic acid (EA), a natural polyphenol abundant in fruits and common in our diet, is under intense investigation for its chemopreventive activity resulting from multiple effects.
Giuseppe Zagotto   +2 more
exaly   +2 more sources

Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells

open access: yesInvestigational New Drugs, 2017
Ellagitannins have been gaining attention as potential anticancer molecules. However, the low bioavailability of ellagitannins and their extensive metabolization in the gastrointestinal tract into ellagic acid and urolithins suggest that the health ...
Joana Liberal   +2 more
exaly   +2 more sources

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

open access: yesMolecular Nutrition and Food Research, 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This document is the Published version of a Published Work that appeared in final form in Molecular Nutrition & Food Research.
Maria Angeles Núñez-Sánchez   +2 more
exaly   +2 more sources

Ellagic Acid and Urolithins A and B Differentially Regulate Fat Accumulation and Inflammation in 3T3-L1 Adipocytes While Not Affecting Adipogenesis and Insulin Sensitivity

open access: yesInternational Journal of Molecular Sciences, 2020
Ellagic acid (EA) is a component of ellagitannins, present in crops such as pecans, walnuts, and many berries, which metabolized by the gut microbiota forms urolithins A, B, C, or D. In this study, ellagic acid, as well as urolithins A and B, were tested
Luis Cisneros-Zevallos   +2 more
exaly   +2 more sources

Urolithin B loaded in cerium oxide nanoparticles enhances the anti-glioblastoma effects of free urolithin B in vitro

Journal of Trace Elements in Medicine and Biology, 2023
Glioblastoma multiforme (GBM) is the most aggressive kind of malignant primary brain tumor in humans. Given the limitation of Conventional therapeutic strategy, the development of nanotechnology and natural product therapy seems to be an effective method enhancing the prognosis of GBM patients.
Ghasem Rahimi-Kalateh Shah Mohammad   +5 more
openaire   +2 more sources

Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells

Journal of Agricultural and Food Chemistry, 2017
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang   +3 more
openaire   +2 more sources

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