Results 11 to 20 of about 23,614 (207)

Aging-Associated Changes in Oxidative Stress Negatively Impacts the Urinary Bladder Urothelium [PDF]

International Neurourology Journal, 2022
Purpose Lower urinary tract symptoms are known to significantly increase with age, negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks, serving as a barrier protecting the underlying bladder tissue from the harsh
Mathijs M. de Rijk, Amanda Wolf-Johnston, Aura F. Kullmann, Stephanie Taiclet, Anthony J. Kanai, Sruti Shiva, Lori A. Birder   +6 more
doaj   +1 more source

Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury

Physiological Reports, 2022
Mice with inducible urothelial deletion of fibroblast growth factor receptor 2 (ShhCreERT2;Fgfr2Fl/Fl) injured with cyclophosphamide had aberrant basal cell endoreplication and poor regeneration.
Sridhar Tatarao Narla, Joanne Lindsey Duara, Daniel Scott Bushnell, Mehdi Nouraie, Jacqueline Holden, Katherine Pfister, Peter C. Lucas, Sunder Sims‐Lucas, Carlton Matthew Bates   +8 more
doaj   +1 more source

Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems

Frontiers in Cellular and Infection Microbiology, 2021
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant proportion of UTI, but a large number of other species can infect the ...
Benjamin O. Murray, Carlos Flores, Corin Williams, Deborah A. Flusberg, Elizabeth E. Marr, Karolina M. Kwiatkowska, Joseph L. Charest, Brett C. Isenberg, Jennifer L. Rohn   +8 more
doaj   +1 more source

A Systematic Review of the (Un)known Host Immune Response Biomarkers for Predicting Recurrence of Urinary Tract Infection

Frontiers in Medicine, 2022
Recurrent urinary tract infections (rUTI) represent a major healthcare and economic burden along with a significant impact on patient’s morbidity and quality of life, even in the absence of well-known risk factors, such as vesicoureteral reflux.
Iva Sorić Hosman, Andrea Cvitković Roić, Andrea Cvitković Roić, Lovro Lamot, Lovro Lamot   +4 more
doaj   +1 more source

Expression of Nectin-4 and Trop-2 in upper tract urothelial carcinoma: implications for biomarker-driven antibody-drug conjugate therapy. [PDF]

J Pathol Clin Res
Abstract Recent advancements in antibody‐drug conjugates, including FDA‐approved therapies targeting Nectin‐4 and Trop‐2, have transformed the cancer treatment landscape, including upper tract urothelial carcinoma (UTUC). However, varied treatment effects and drug‐associated adverse effects raise the question of whether patients should be selected ...
Shi P, Wu Q, Zhang Y, Chen T, Warrick JI, DeGraff DJ, Raman JD, Chen G.   +7 more
europepmc   +2 more sources

Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder

Journal of Pharmacological Sciences, 2016
Muscarinic and purinergic (P2X) receptors play critical roles in bladder urothelium under physiological and pathological conditions. Aim of present study was to characterize these receptors in rat bladder urothelium and detrusor muscle using selective ...
Masaki Ogoda, Yoshihiko Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada   +4 more
doaj   +1 more source

Diabetes-induced alterations in urothelium function:Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder [PDF]

, 2018
Up to 80% of patients with diabetes mellitus develop lower urinary tract complications, most commonly diabetic bladder dysfunction (DBD). The aim of this study was to investigate the impact of diabetes on the function of the inner bladder lining ...
Apodaca, Birder, Birder, Brown, Chaiyaprasithi, Cheng, Cheng, Cho, Daly, Daneshgari, Daneshgari, Daneshgari, Dunning-Davies, Eika, Ferguson, Fovaeus, Frimodt-Moller, Golbidi, Gomez, Hanna-Mitchell, Hanna-Mitchell, Hawthorn, Kang, Knight, Kolta, Kumar, Kumar, Lai, Langdale, Liu, Liu, Longhurst, Malmgren, Mumtaz, Munoz, Munoz, Mustafa, Nirmal, Pinna, Ren, Sadananda, Sellers, Silva-Ramos, Smith, Stella, Sun, Tammela, Templeman, Vahabi, Vahabi, Vlaskovska, Wang, Xiao, Xiao, Yoshida, Yoshimura, Zhao   +56 more
core   +1 more source

Polyploid superficial cells that maintain the urothelial barrier are produced via incomplete cytokinesis and endoreplication [PDF]

, 2018
Summary: The urothelium is an epithelia barrier lined by a luminal layer of binucleated, octoploid, superficial cells. Superficial cells are critical for production and transport of uroplakins, a family of proteins that assemble into a waterproof ...
Batourina, Ekatherina, Canman, Julie C, Dan, Hanbin, George, Christopher D, Liu, Chang, Mendelsohn, Cathy Lee, Mysorekar, Indira U, Schneider, Kerry, Souza, Spenser, Swayne, Theresa, Tate, Tiffany, Wang, Jia, Wiessner, Gregory, Zhuravlev, Yelena   +13 more
core   +3 more sources

Cascade bioassay evidence for the existence of urothelium-derived inhibitory factor in Guinea pig urinary bladder.

PLoS ONE, 2014
Our aim was to investigate whether guinea pig urothelium-derived bioactivities compatible with the existence of urothelium-derived inhibitory factor could be demonstrated by in vitro serial bioassay and whether purinergic P1 receptor agonists, nitric ...
Na N Guan, Anna Thor, Katarina Hallén, N Peter Wiklund, Lars E Gustafsson   +4 more
doaj   +1 more source

Improved Urothelial Cell Proliferation, Cytoskeleton and Barrier Function Protein Expression in the Patients With Interstitial Cystitis/Bladder Pain Syndrome After Intravesical Platelet-Rich Plasma Injection [PDF]

International Neurourology Journal, 2022
Purpose To investigate urothelial cell proliferation, cytoskeleton, inflammation, and barrier function protein expressions in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) after intravesical platelet-rich plasma (PRP) injections ...
Jia-Fong Jhang, Yuan-Hong Jiang, Yung-Hsiang Hsu, Han-Chen Ho, Lori A Birder, Teng-Yi Lin, Hann-Chorng Kuo   +6 more
doaj   +1 more source