Results 31 to 40 of about 4,974 (168)

UPEC Colonic-Virulence and Urovirulence Are Blunted by Proanthocyanidins-Rich Cranberry Extract Microbial Metabolites in a Gut Model and a 3D Tissue-Engineered Urothelium

Microbiology Spectrum, 2022
Uropathogenic Escherichia coli (UPEC) ecology-pathophysiology from the gut reservoir to its urothelium infection site is poorly understood, resulting in equivocal benefits in the use of cranberry as prophylaxis against urinary tract infections.
Charlène Roussel, Stéphane Chabaud, Jacob Lessard-Lord, Valentina Cattero, Félix-Antoine Pellerin, Perrine Feutry, Valérie Bochard, Stéphane Bolduc, Yves Desjardins   +8 more
doaj   +1 more source

Loss of Janus Associated Kinase 1 Alters Urothelial Cell Function and Facilitates the Development of Bladder Cancer

Frontiers in Immunology, 2019
Inherited Primary Immunodeficiency (PID) disorders are associated with increased risk of malignancy that may relate to impaired antitumor immune responses or a direct role for PID germline mutations in tumorigenesis.
Vanessa Daza-Cajigal, Vanessa Daza-Cajigal, Vanessa Daza-Cajigal, Vanessa Daza-Cajigal, Vanessa Daza-Cajigal, Adriana S. Albuquerque, Joanna Pearson, Jennifer Hinley, Andrew S. Mason, Jens Stahlschmidt, Jens Stahlschmidt, Adrian J. Thrasher, Adrian J. Thrasher, Vibhash Mishra, Jennifer Southgate, Siobhan O. Burns, Siobhan O. Burns   +16 more
doaj   +1 more source

Pathophysiology of the urothelium and detrusor [PDF]

Canadian Urological Association Journal, 2011
Conventional wisdom now agrees that symptoms of overactivebladder (OAB) seem to emanate from an aberration in the voidingreflex, leading to involuntary detrusor contractions of eitherneurogenic or myogenic origin. Furthermore, emerging evidencealso encourages us to adopt a new paradigm, in which bladderurothelium is not just a simple barrier but an ...
openaire   +3 more sources

Urine-Derived Stem Cells for Epithelial Tissues Reconstruction and Wound Healing

Pharmaceutics, 2022
Epithelial tissue injury can occur on any surface site of the body, particularly in the skin or urethral mucosa tissue, due to trauma, infection, inflammation, and toxic compounds.
Xiya Yin, Qingfeng Li, Patrick Michael McNutt, Yuanyuan Zhang   +3 more
doaj   +1 more source

A Biomimetic Porcine Urothelial Model for Assessing Escherichia coli Pathogenicity

Microorganisms, 2022
Urinary tract infections can be severe, sometimes fatal, diseases whose etiological pathogens are predominantly uropathogenic strains of E. coli (UPEC).
Luka Predojević, Darja Keše, Darja Žgur Bertok, Taja Železnik Ramuta, Peter Veranič, Mateja Erdani Kreft, Marjanca Starčič Erjavec   +6 more
doaj   +1 more source

Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases

Frontiers in Physiology, 2022
Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many cell ...
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A. Perrino, Violeta N. Mutafova-Yambolieva   +4 more
doaj   +1 more source

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of Non-neuronal Acetylcholine in Urothelium and Its Clinical Significance

Journal of Pharmacological Sciences, 2008
Recently, several reports demonstrate that non-neuronal acetylcholine (ACh) release may contribute to various pathophysiological conditions. In this review, we presented our experiments designed to evaluate the non-neuronal cholinergic system in human ...
Masaki Yoshida, Koichi Masunaga, You Satoji, Yoshihiro Maeda, Takashi Nagata, Akito Inadome   +5 more
doaj   +1 more source

Gliding Basal Cell Migration of the Urothelium during Wound Healing [PDF]

, 2018
Collective cell migration during wound healing has been extensively studied in the epidermis. However, it remains unknown whether the urothelium repairs wounds in a manner similar to the epidermis.
Ogawa, Osamu, Kobayashi, Takashi, Matsuda, Michiyuki, Sano, Takeshi   +3 more
core   +1 more source

Combined lectin- and immuno-histochemistry (CLIH) for applications in cell biology and cancer diagnosis: Analysis of human urothelial carcinomas

European Journal of Histochemistry, 2020
Lectin histochemistry (LHC) and immunohistochemistry (IHC), which demonstrate the composition and localisation of sugar residues and proteins in cell membranes, respectively, are generally used separately.
Daša Zupančič, Mateja Erdani Kreft, Igor Sterle, Rok Romih   +3 more
doaj   +1 more source

TRPA1 channel mediates methylglyoxal-induced mouse bladder dysfunction

Frontiers in Physiology, 2023
Introduction: The transient receptor potential ankyrin 1 channel (TRPA1) is expressed in urothelial cells and bladder nerve endings. Hyperglycemia in diabetic individuals induces accumulation of the highly reactive dicarbonyl compound methylglyoxal (MGO),
Akila L. Oliveira, Matheus L. Medeiros, Erick de Toledo Gomes, Glaucia Coelho Mello, Soraia Katia Pereira Costa, Fabíola Z. Mónica, Edson Antunes   +6 more
doaj   +1 more source