Results 21 to 30 of about 23,871 (225)

Aging-Associated Changes in Oxidative Stress Negatively Impacts the Urinary Bladder Urothelium [PDF]

International Neurourology Journal, 2022
Purpose Lower urinary tract symptoms are known to significantly increase with age, negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks, serving as a barrier protecting the underlying bladder tissue from the harsh
Mathijs M. de Rijk, Amanda Wolf-Johnston, Aura F. Kullmann, Stephanie Taiclet, Anthony J. Kanai, Sruti Shiva, Lori A. Birder   +6 more
doaj   +1 more source

Signalling Molecules in the Urothelium [PDF]

BioMed Research International, 2014
The urothelium was long considered to be a silent barrier protecting the body from the toxic effects of urine. However, today a number of dynamic abilities of the urothelium are well recognized, including its ability to act as a sensor of the intravesical environment. During recent years several pathways of these urothelial abilities have been proposed
Winder, Michael, Tobin, Gunnar, Zupančič, Daša, Romih, Rok   +3 more
openaire   +2 more sources

Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder

Journal of Pharmacological Sciences, 2016
Muscarinic and purinergic (P2X) receptors play critical roles in bladder urothelium under physiological and pathological conditions. Aim of present study was to characterize these receptors in rat bladder urothelium and detrusor muscle using selective ...
Masaki Ogoda, Yoshihiko Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada   +4 more
doaj   +1 more source

Diabetes-induced alterations in urothelium function:Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder [PDF]

, 2018
Up to 80% of patients with diabetes mellitus develop lower urinary tract complications, most commonly diabetic bladder dysfunction (DBD). The aim of this study was to investigate the impact of diabetes on the function of the inner bladder lining ...
Apodaca, Birder, Birder, Brown, Chaiyaprasithi, Cheng, Cheng, Cho, Daly, Daneshgari, Daneshgari, Daneshgari, Dunning-Davies, Eika, Ferguson, Fovaeus, Frimodt-Moller, Golbidi, Gomez, Hanna-Mitchell, Hanna-Mitchell, Hawthorn, Kang, Knight, Kolta, Kumar, Kumar, Lai, Langdale, Liu, Liu, Longhurst, Malmgren, Mumtaz, Munoz, Munoz, Mustafa, Nirmal, Pinna, Ren, Sadananda, Sellers, Silva-Ramos, Smith, Stella, Sun, Tammela, Templeman, Vahabi, Vahabi, Vlaskovska, Wang, Xiao, Xiao, Yoshida, Yoshimura, Zhao   +56 more
core   +1 more source

Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma [PDF]

, 2020
Psychological stress is associated with bladder dysfunction, however, the local bladder mechanisms affected are not well understood. This study aimed to determine how psychological stress, caused by social defeat or witness trauma, affects voiding ...
Chess-Williams, Russ, McDermott, Catherine, Sellers, Donna J, West, Eliza   +3 more
core   +1 more source

Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice [PDF]

, 2014
Although somatic mutations and overexpression of the tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) are strongly associated with bladder cancer, evidence for their functional involvement in the pathogenesis remains elusive.
Ahmad, Ahmad, Ahmad, Askham, Billerey, Brooks, Calderaro, Castillo-Martin, Chesi, Cho, Duenas, Dupuy, Gavine, Goetz, Guagnano, Herr, Iwata, Iwata, Iwata, Jebar, Juanpere, Knowles, Kompier, Kong, Korkolopoulou, Laederich, Lamont, Lamy, Lesche, Lindgren, Logie, Lopez-Knowles, Mo, Novak, Platt, Puzio-Kuter, Qing, Rhijn, Ross, Shin, Sjodahl, Stenzl, Tomlinson, Tomlinson, Tsuruta, Yohn, Yoo, Zhang, Zieger   +48 more
core   +1 more source

Cascade bioassay evidence for the existence of urothelium-derived inhibitory factor in Guinea pig urinary bladder.

PLoS ONE, 2014
Our aim was to investigate whether guinea pig urothelium-derived bioactivities compatible with the existence of urothelium-derived inhibitory factor could be demonstrated by in vitro serial bioassay and whether purinergic P1 receptor agonists, nitric ...
Na N Guan, Anna Thor, Katarina Hallén, N Peter Wiklund, Lars E Gustafsson   +4 more
doaj   +1 more source

5-HT2A receptor enhancement of contractile activity of the porcine urothelium and lamina propria [PDF]

, 2016
OBJECTIVES: To examine the effect of 5-hydroxytryptamine (5-HT; serotonin) on the contractile properties of the urothelium and lamina propria, as a better understanding of bladder physiology might aid the development of new treatments.METHODS: Strips of ...
Alexander, Andersson, Baxter, Berger, Birder, Blakeman, Blanco, Bschleipfer, Chapple, Gillespie, Ikeda, Imamura, Kanai, Lecci, Liang, Masunaga, Matsumoto-Miyai, Moro, Moro, Moro, Moro, Pfeiffer, Rahnama'i, Rahnama'i, Recio, Rekik, Sadananda, Sellers, Sleight, Wang   +29 more
core   +1 more source

The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor [PDF]

, 2020
BACKGROUND: Inflammation is often associated with several bladder dysfunctions, including overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS).
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Is the urothelium intelligent? [PDF]

Neurourology and Urodynamics, 2010
AbstractThe urothelium separates the urinary tract lumen from underlying tissues of the tract wall. Previously considered as merely an effective barrier between these two compartments it is now recognized as a more active tissue that senses and transduces information about physical and chemical conditions within the urinary tract, such as luminal ...
Birder, LA, Kanai, AJ, Cruz, F, Moore, K, Fry, CH   +4 more
openaire   +3 more sources