Is the urothelium intelligent? [PDF]
Neurourology and Urodynamics, 2010 AbstractThe urothelium separates the urinary tract lumen from underlying tissues of the tract wall. Previously considered as merely an effective barrier between these two compartments it is now recognized as a more active tissue that senses and transduces information about physical and chemical conditions within the urinary tract, such as luminal ...
Birder, LA +4 more
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The differentiation of human adipose-derived stem cells towards a urothelium-like phenotype in vitro and the dynamic temporal changes of related cytokines by both paracrine and autocrine signal regulation. [PDF]
PLoS ONE, 2014 PURPOSE: To investigate the differentiation ability of human adipose-derived stem cells (ASCs) towards urothelium-like cells in vitro and the dynamic changes of related cytokines and cytokine receptors in the culture medium.
Ming Zhang +7 more
doaj +1 more source
Urothelial cancers of the bladder in young people [PDF]
Vojnosanitetski Pregled, 2003 Tumors of the bladder, particularly urothelial carcinoma (UC) are very rare malignant diseases in young people. They mostly occur in elder persons of male gender.
Živković Slađana +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Inflammatory conditions of the urinary bladder have been shown to be associated with urothelial damage and loss of function. The purinergic P2X7 receptor has been implicated in several inflammatory conditions. The aim of this study was to investigate the
Zhinoos Taidi +4 more
doaj +1 more source
Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury
Physiological Reports, 2022 Mice with inducible urothelial deletion of fibroblast growth factor receptor 2 (ShhCreERT2;Fgfr2Fl/Fl) injured with cyclophosphamide had aberrant basal cell endoreplication and poor regeneration.
Sridhar Tatarao Narla +8 more
doaj +1 more source
Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems
Frontiers in Cellular and Infection Microbiology, 2021 Urinary tract infections (UTIs) are among the most common infectious diseases worldwide but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant proportion of UTI, but a large number of other species can infect the ...
Benjamin O. Murray +8 more
doaj +1 more source
Frontiers in Medicine, 2022 Recurrent urinary tract infections (rUTI) represent a major healthcare and economic burden along with a significant impact on patient’s morbidity and quality of life, even in the absence of well-known risk factors, such as vesicoureteral reflux.
Iva Sorić Hosman +4 more
doaj +1 more source
Aging-Associated Changes in Oxidative Stress Negatively Impacts the Urinary Bladder Urothelium [PDF]
International Neurourology Journal, 2022 Purpose Lower urinary tract symptoms are known to significantly increase with age, negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks, serving as a barrier protecting the underlying bladder tissue from the harsh
Mathijs M. de Rijk +6 more
doaj +1 more source
Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl [PDF]
, 2012 It is generally considered that the bladder is impervious and stores urine in unmodified form on account of the barrier imposed by the highly-specialised uro-epithelial lining.
Lisa A Kirkwood +14 more
core +2 more sources
Down-Regulation of Annexin A1 in the Urothelium Decreases Cell Survival After Bacterial Toxin Exposure [PDF]
, 2013 PURPOSE: We examined the role of annexins in bladder urothelium. We characterized expression and distribution in normal bladders, biopsies from patients with bladder pain syndrome, cultured human urothelium and urothelial TEU-2 cells. MATERIALS AND
Babiychuk, Eduard B. +3 more
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