Urea Transporter UT-B Deletion Induces DNA Damage and Apoptosis in Mouse Bladder Urothelium [PDF]
PLoS ONE, 2013 BackgroundPrevious studies found that urea transporter UT-B is abundantly expressed in bladder urothelium. However, the dynamic role of UT-B in bladder urothelial cells remains unclear.
Jianhua Ran, Jihui Chen, Tianluo Lei
exaly +2 more sources
Spatial transcriptomic map of the mouse urinary bladder [PDF]
Scientific ReportsWe present a spatial transcriptomic map of the mouse urinary bladder at near single-cell resolution using Visium HD technology with 8 × 8 μm bins. After quality filtering, we analyzed 66,471 bins and 9,364 genes.
Nives Matković +10 more
doaj +2 more sources
The Urothelium: Life in a Liquid Environment
Physiological Reviews, 2020 The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra, forms a high-resistance but adaptable barrier that surveils its mechanochemical environment and communicates changes to underlying tissues including afferent nerve fibers and the smooth muscle.
Marianela G Dalghi +2 more
exaly +4 more sources
CBD Promotes Structural and Functional Epithelial Restoration and Alleviates Inflammation in a Mouse Model of Interstitial Cystitis [PDF]
PharmaceuticsBackground: Interstitial cystitis (IC) is a debilitating lower urinary tract condition characterised by chronic inflammation of the bladder. As the aetiology remains unknown, current treatments are symptomatic, aiming to reduce inflammation and pain ...
Dominika Peskar +6 more
doaj +2 more sources
FASLG Derived from Fibroblasts in Hydroxyapatite-Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure. [PDF]
Adv Sci (Weinh)Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Liu M +14 more
europepmc +2 more sources
Acellular foreskin dermal matrix is efficient in supporting the growth of urothelial cells derived from hypospadias patients [PDF]
Frontiers in PediatricsIntroductionHypospadias is a common congenital defect in males, with surgery remaining the primary treatment option. However, urethral reconstruction procedures often require additional tissue transplantation, which is limited by the availability of ...
Zhiqing Cao +4 more
doaj +2 more sources
Prognostic impact of perirenal fat stranding on oncologic outcomes in ureteral urothelial carcinoma [PDF]
Investigative and Clinical Urology, 2021 Purpose: Perirenal fat stranding (PRFS) is defined as linear areas of soft-tissue attenuation in the perirenal space that can result from ureteral obstruction.
Jae-Wook Chung +11 more
doaj +1 more source
Antioxidants, 2022 It is now well established that the urothelium does not act as a passive barrier but contributes to bladder homeostasis by releasing several signaling molecules in response to physiological and chemical stimuli.
Emma Mitidieri +12 more
doaj +1 more source
Is the urothelium intelligent? [PDF]
Neurourology and Urodynamics, 2010 AbstractThe urothelium separates the urinary tract lumen from underlying tissues of the tract wall. Previously considered as merely an effective barrier between these two compartments it is now recognized as a more active tissue that senses and transduces information about physical and chemical conditions within the urinary tract, such as luminal ...
Birder, LA +4 more
openaire +4 more sources
The differentiation of human adipose-derived stem cells towards a urothelium-like phenotype in vitro and the dynamic temporal changes of related cytokines by both paracrine and autocrine signal regulation. [PDF]
PLoS ONE, 2014 PURPOSE: To investigate the differentiation ability of human adipose-derived stem cells (ASCs) towards urothelium-like cells in vitro and the dynamic changes of related cytokines and cytokine receptors in the culture medium.
Ming Zhang +7 more
doaj +1 more source