Results 61 to 70 of about 23,614 (207)

Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis

Frontiers in Surgery, 2018
Diabetic bladder dysfunction (DBD) is a well-recognized and common symptom affecting up to 50% of all diabetic patients. DBD has a broad range of clinical presentations ranging from overactive to underactive bladder symptoms that develops in middle-aged ...
Nicole S. Klee, Cameron G. McCarthy, Steven Lewis, Jaine L. McKenzie, Jaine L. McKenzie, Julie E. Vincent, R. Clinton Webb   +6 more
doaj   +1 more source

Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development. [PDF]

, 2017
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald, Isaacson, Dylan, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +6 more
core   +2 more sources

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Immunohistochemistry as a paramount tool in research of normal urothelium, bladder cancer and bladder pain syndrome

European Journal of Histochemistry, 2021
The urothelium, an epithelium of the urinary bladder, primarily functions as blood-urine permeability barrier. The urothelium has a very slow turn-over under normal conditions but is capable of extremely fast response to injury.
Daša Zupančič, Rok Romih
doaj   +1 more source

A pH-sensitive stearoyl-PEG-poly(methacryloyl sulfadimethoxine)-decorated liposome system for protein delivery: an application for bladder cancer treatment [PDF]

, 2016
Stealth pH-responsive liposomes for the delivery of therapeutic proteins to the bladder epithelium were prepared using methoxy-poly(ethylene glycol)5kDa-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (mPEG5kDa-DSPE) and stearoyl-poly(ethylene glycol ...
Balasso, Anna, Codolo, Gaia, DE BERNARD, Marina, Fassan, Matteo, Malfanti, Alessio, Munari, Fabio, Rugge, Massimo, Salmaso, Stefano, Vila Caballer, Marian   +8 more
core   +1 more source

Reconstruction of deep and perforating corneal defects in dogs—A review (Part III/III): The use of corneal sutures and reporting of ocular discomfort

Veterinary Ophthalmology, Volume 28, Issue 2, Page 543-552, March 2025.
Abstract The surgical reconstruction of severe corneal disease is a common and crucial component of the clinical practice of veterinary ophthalmology. The first part of the present review described procedures that utilize autogenous ocular tissues, homologous donor tissues, and heterologous donor tissues in dogs, while the second part reviewed the use ...
R. F. Sanchez
wiley   +1 more source

Altered expression of transmembrane mucins, MUC1 and MUC4, in bladder cancer: pathological implications in diagnosis. [PDF]

PLoS ONE, 2014
Radical changes in both expression and glycosylation pattern of transmembrane mucins have been observed in various malignancies. We and others have shown that MUC1 and MUC4, two transmembrane mucins, play a sentinel role in cell signaling events that ...
Sukhwinder Kaur, Navneet Momi, Subhankar Chakraborty, David G Wagner, Adam J Horn, Subodh M Lele, Dan Theodorescu, Surinder K Batra   +7 more
doaj   +1 more source

Cellular microenvironment of erythropoietin‐producing cells in hypoxic and injured mouse kidneys

Experimental Physiology, EarlyView.
Abstract The main sources of circulating erythropoietin (Epo) in the adult are kidney Norn cells, a recently identified interstitial cell type capable of becoming renal Epo‐producing (REP) cells following a local decrease in tissue oxygenation. REP cells are restricted to small clusters in the corticomedullary border region, suggesting that their ...
Olga M. Lempke, Thomas Knöpfel, Stellor Nlandu Khodo, Roland H. Wenger   +3 more
wiley   +1 more source

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner

Metabolites, 2022
Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz, Mafalda S. L. Aresta Branco, Brian A. Perrino, Kenton M. Sanders, Violeta N. Mutafova-Yambolieva   +4 more
doaj   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source