Results 91 to 100 of about 5,130,717 (259)

Conservative treatment of cholelithiasis: the effectiveness of the use of ursodeoxycholic acid

, 2023
N. D. Karseladze, Sergey A. Makhnev, Yu. S. Sayfutdinova   +2 more
openalex   +1 more source

Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, EarlyView.
In a multi‐centre study of obeticholic acid in primary biliary cholangitis, 45% discontinued the drug over 4 years, with 11% moving to combination therapy (fibrates). Of those continuing, response rates increased from 37% (1 year) to 55% (4 years). Non‐response at 12 months and cirrhosis were independent predictors of liver‐related events.
Nadir Abbas, Rachel Smith, Ellina Lytvyak, Miki Scaravaglio, Neil Halliday, Amal Almahroos, Nadia Eden, Diane Lloyd‐Madden, Sanchit Sharma, James Ferguson, Jessica K. Dyson, Douglas Thorburn, David Jones, Aldo J. Montano‐Loza, Marco Carbone, Pietro Invernizzi, George Mells, Emma L. Culver, Palak J. Trivedi   +18 more
wiley   +1 more source

Risk of acute pancreatitis with DPP‐4 inhibitors versus SGLT2 inhibitors in medication‐naïve individuals with diabetes: A target trial emulation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims We investigated whether dipeptidyl peptidase‐4 inhibitor (DPP‐4i) use was associated with a higher risk of acute pancreatitis compared with sodium–glucose cotransporter 2 inhibitor (SGLT2i) use in antidiabetic medication‐naïve individuals.
Takashi Tatewaki, Akira Okada, Yuya Kimura, Hideo Yasunaga   +3 more
wiley   +1 more source

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction

Scientific Reports, 2018
Ursodeoxycholic acid (UDCA) is a metabolic by-product of intestinal bacteria, showing hepatoprotective effects. However, its underlying molecular mechanisms remain unclear.
D. Kim, Seonghae Yoon, S. Ji, Jinho Yang, Yoon-Keun Kim, SeungHwan Lee, K. Yu, I. Jang, J. Chung, Joo-Youn Cho   +9 more
semanticscholar   +1 more source

Detection of Ursid Gammaherpesvirus 2 in Asiatic Black Bears (Ursus thibetanus) With Keratoconjunctivitis

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objective To investigate the potential contribution of herpesvirus infection in the development of ocular surface disease in Asiatic black bears (Ursus thibetanus). Animals Studied Eight captive Asiatic black bears housed at a wildlife sanctuary were examined during routine health assessments.
Katharina Thieme, Marc Gölkel, J. Corinna Eule, Lesley Halter‐Gölkel, Dusan Kunec, Frank Göritz, Sina Feyer, Bich Ngoc Bui, Jakob Trimpert   +8 more
wiley   +1 more source

Ursodeoxycholic acid therapy in children with cholestatic liver disease

The Turkish Journal of Pediatrics, 1999
The beneficial effect of ursodeoxycholic acid have been documented in adults but experience with this agent is limited in the pediatric population. The objective of this study was to evaluate ursodeoxycholic acid treatment in children with cholestatic ...
Gönül Dinler, Nurten Koçak, Aysel Yüce, Figen Gürakan, Hasan Özen   +4 more
doaj   +1 more source

Clinicopathological Characteristics With the Status of Mismatch Repair Deficient Invasive Colorectal Cancer With Spontaneous Regression

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Spontaneous regression of endoscopically invasive colorectal cancer (CRC) after biopsy has been rarely reported. We report three cases of endoscopically invasive CRC with spontaneous regression after biopsy and a review of the literature regarding spontaneous regression of CRC with somatic mismatch repair deficiency (MMR‐d).
Fumiya Okano, Naohisa Yoshida, Yukiko Morinaga, Naoto Iwai, Reo Kobayashi, Ken Inoue, Osamu Dohi, Takashi Ando, Yoshito Itoh   +8 more
wiley   +1 more source

Evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for ursodeoxycholic acid, and 7 oxo- and 12 oxo- bile acids

Journal of Lipid Research, 1980
3 alpha-Hydroxysteroid dehydrogenase (SDH) quantifies ursodeoxycholic acid, 3 alpha,12 alpha-diol-7-one-5 beta-cholanoic acid, 3 alpha-ol-7-one-5 beta-cholanoic acid, and 3 alpha,7 alpha-diol-12-one-5 beta-cholanoic acid in a manner similar to the more ...
L J Haeffner, S J Gordon, J S Magen, O D Kowlessar   +3 more
doaj   +1 more source