Results 141 to 150 of about 59,675,237 (384)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Usability Testing: Open GeoPortal 2.0 [PDF]

open access: yes, 2014
The PLACE project team at the University of New Hampshire Library performed usability testing on May 9, 2014 with three participants with GIS experience. Tasks focused on use of Open GeoPortal 2.0 (beta)
Parker, Kristin, Wolff, Rob
core   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Less Complexity in Hemodialysis Machines Reduces Time and Physical Load for Operator Actions

open access: yesMedical Devices: Evidence and Research, 2021
Uwe Gründler,1 Eva Ekesbo,2 Martin Löwe,1 Adelheid Gauly3 1REFA Consulting AG, Dortmund, Germany; 2BetaHälsan AB, Lund, Sweden; 3Fresenius Medical Care, Global Medical Office, Bad Homburg, GermanyCorrespondence: Adelheid GaulyFresenius Medical Care ...
Gründler U, Ekesbo E, Löwe M, Gauly A
doaj  

The Use of Starch Chromatography and Ion Exchange Resin for Large Scale Separations of N15-Labeled Amino Acids. [PDF]

open access: bronze, 1951
S. Åqvist   +4 more
openalex   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

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