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CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer
Pathology Research and Practice, 2019Breast cancer is the most common malignant tumor among women in China, which seriously threatens women's physical and mental health. Tumorigenesis is closely related to the dysregulation of cell cycle. The cell cycle progression includes interphase and mitotic phase (M phase). Cyclin B1 is a key protein in regulating M phase, which is essential for the
Caifeng Xie, Tianyu Han, Jiaqing Cao
exaly +3 more sources
Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila
Journal of VirologyABSTRACT Cactin, a highly conserved protein, plays a crucial role in various physiological processes in eukaryotes, including innate immunity. Recently, the function of Cactin in the innate immunity of Drosophila has been explored, revealing that Cactin regulates a non ...
Qiqi Rong +5 more
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2019
The ubiquitin-proteasome pathway plays an essential role in maintaining protein homeostasis and regulates almost every aspect of cellular processes in eukaryotes. Emerging evidence indicates that the proteasome does not work as a simple unidirectional molecular machinery for substrate proteolysis.
Muniyappan, Srinivasan, Lee, Byung-Hoon
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The ubiquitin-proteasome pathway plays an essential role in maintaining protein homeostasis and regulates almost every aspect of cellular processes in eukaryotes. Emerging evidence indicates that the proteasome does not work as a simple unidirectional molecular machinery for substrate proteolysis.
Muniyappan, Srinivasan, Lee, Byung-Hoon
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USP14 Inhibitors as Potential Anticancer Agents
Future Medicinal Chemistry, 2018Stina, Lundgren, Ewa, Odrzywol
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THE UBIQUITIN-SPECIFIC PROTEASE USP14 CONTROLS CILIOGENESIS AND THE HEDGEHOG PATHWAY
2018Primary cilia are microtubule-based organelles on the apical surface of mammalian cells, and play a crucial role in vertebrate development and tissue homeostasis. Consequently, ciliary defects are associated with human disorders called ciliopathies. This organelle represents an organizing center for signaling pathways.
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