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International Journal of Molecular Sciences, 2013 The deubiquitinating enzyme USP14 has been identified and biochemically studied, but its role in lung cancer remains to be elucidated. The aim of this study was to evaluate the prognostic significance of USP14 in patients with lung adenocarcinoma and to ...
Chong Bai +2 more
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USP14 inhibits ER-associated degradation via interaction with IRE1α
Biochemical and Biophysical Research Communications, 2009Accumulation of unfolded proteins within the endoplasmic reticulum (ER) lumen induces ER stress. Eukaryotic cells possess the ER quality control systems, the unfolded protein response (UPR), to adapt to ER stress. IRE1alpha is one of the ER stress receptors and mediates the UPR.
Hidenori Ichijō +2 more
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CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer
Pathology Research and Practice, 2019Breast cancer is the most common malignant tumor among women in China, which seriously threatens women's physical and mental health. Tumorigenesis is closely related to the dysregulation of cell cycle. The cell cycle progression includes interphase and mitotic phase (M phase). Cyclin B1 is a key protein in regulating M phase, which is essential for the
Caifeng Xie, Tianyu Han, Jiaqing Cao
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2019
The ubiquitin-proteasome pathway plays an essential role in maintaining protein homeostasis and regulates almost every aspect of cellular processes in eukaryotes. Emerging evidence indicates that the proteasome does not work as a simple unidirectional molecular machinery for substrate proteolysis.
Muniyappan, Srinivasan, Lee, Byung-Hoon
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The ubiquitin-proteasome pathway plays an essential role in maintaining protein homeostasis and regulates almost every aspect of cellular processes in eukaryotes. Emerging evidence indicates that the proteasome does not work as a simple unidirectional molecular machinery for substrate proteolysis.
Muniyappan, Srinivasan, Lee, Byung-Hoon
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Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila
Journal of VirologyABSTRACT Cactin, a highly conserved protein, plays a crucial role in various physiological processes in eukaryotes, including innate immunity. Recently, the function of Cactin in the innate immunity of Drosophila has been explored, revealing that Cactin regulates a non ...
Qiqi Rong +5 more
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USP14 Inhibitors as Potential Anticancer Agents
Future Medicinal Chemistry, 2018Stina, Lundgren, Ewa, Odrzywol
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