Results 151 to 160 of about 3,826 (176)

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling [PDF]

Oncogenesis, 2013
Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl. Mutations in the RDU resulted in accumulation of polyubiquitinated forms of Dvl, which were mainly K63 linked.
Madelon M Maurice, Min Jae Lee
exaly   +7 more sources

USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination [PDF]

Autophagy, 2018
Recent reports have made important revelations, uncovering direct regulation of DNA damage response (DDR)-associated proteins and chromatin ubiquitination (Ubn) by macroautophagy/autophagy. Here, we report a previously unexplored connection between autophagy and DDR, via a deubiquitnase (DUB), USP14.
Arishya Sharma, Kamini Singh, Payel Chatterjee   +2 more
exaly   +4 more sources

USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis

Naunyn-Schmiedeberg's Archives of Pharmacology
AbstractThe aim of this study is to explore the function of USP14 on the sensitivity of retinoblastoma (RB) to cisplatin (DDP) and the underlying mechanism. USP14 was knockdown in Y79 cells by transfecting three siRNAs (si-USP14-1, si-USP14-2, and si-USP14-3), with si-USP14 NC as the negative control.
Jiayue Li, Yong Chai, Jin Qifang
exaly   +3 more sources

Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of β-Catenin

International Journal of Molecular Sciences, 2013
The deubiquitinating enzyme USP14 has been identified and biochemically studied, but its role in lung cancer remains to be elucidated. The aim of this study was to evaluate the prognostic significance of USP14 in patients with lung adenocarcinoma and to ...
Chong Bai, William C Cho, Cho William C S   +2 more
exaly   +2 more sources

USP 14 inhibition corrects an in vivo model of impaired mitophagy [PDF]

EMBO Molecular Medicine, 2018
Mitochondrial autophagy or mitophagy is a key process that allows selective sequestration and degradation of dysfunctional mitochondria to prevent excessive reactive oxygen species, and activation of cell death.
Joy Chakraborty, Elena Marchesan, Federico Caicci   +2 more
exaly   +2 more sources

Inhibition of USP14 suppresses the formation of foam cell by promoting CD36 degradation [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractAtherosclerosis is regarded as a chronic progressive inflammatory disease and is a basic pathophysiological process in coronary artery disease which is life threatening in clinic. The formation of foam cell plays a key role in the pathogenesis of atherosclerosis. OxLDL is a significant factor in progression of coronary artery disease.
Fangcheng Zhang, Xiaohong Xia, Mingke Liu   +2 more
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

USP14 inhibits ER-associated degradation via interaction with IRE1α

Biochemical and Biophysical Research Communications, 2009
Accumulation of unfolded proteins within the endoplasmic reticulum (ER) lumen induces ER stress. Eukaryotic cells possess the ER quality control systems, the unfolded protein response (UPR), to adapt to ER stress. IRE1alpha is one of the ER stress receptors and mediates the UPR.
Takeshi Maruyama, Kohsuke Takeda, Hideki Nishitoh   +2 more
exaly   +3 more sources