Results 121 to 130 of about 984,321 (234)

Fluoride as a Modifier of Metallome Homeostasis: A Systematic Review of Animal Studies

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Fluoride is widely used for caries prevention due to its effects on mineralized tissues, yet its potential role as a modifier of systemic metal homeostasis remains insufficiently explored. This systematic review synthesizes preclinical evidence on the association between fluoride exposure and changes in metal and semi‐metal concentrations ...
Natalia Macedo‐Ribeiro, Jonas Tostes‐Figueiredo, Davi da Silva Barbirato, Isabel Maria Porto, Eliude Barbosa Gomes, Erico Marlon Moraes Flores, Marília Afonso Rabelo Buzalaf, Fernando Barbosa Jr, Raquel Fernanda Gerlach   +8 more
wiley   +1 more source

Volúmenes específicos parciales de componentes en sistemas agua – alcohol usp – sorbitol usp/nf

, 2001
A partir de los valores de densidad de diferentes mezclas representativas de los sistemas cosolventes, agua – alcohol USP – sorbitol USP  y  agua – alcohol USP – sorbitol NF, se calcularon los volúmenes específicos parciales de las sustancias ...
Rodriguez, Sylvia, Barbosa, Helber, Pinzón, Jorge, Martínez, Fleming   +3 more
core  

GMP‐compliant production, validation and dosimetry of clinical grade [18F]3‐(3‐fluoropropyl)‐2‐phenyl‐2,3‐dihydrobenzo[d]thiazole ([18F]FPBT) for oxidative stress PET imaging

British Journal of Pharmacology, Volume 183, Issue 20, Page 6028-6045, October 2026.
Background and Purpose Oxidative stress plays a critical role in the pathophysiology of various diseases, yet current methods for its non‐invasive detection remain limited. This study aimed to systematically validate a superoxide‐selective PET tracer, [18F]FPBT, for the early diagnosis and therapeutic monitoring of oxidative stress‐related conditions ...
Hua Zhang, Fangfang Sun, Chun Li, Xin Wang, Yuexuan Song, Lu Jiang, Paul Gape, Samantha Y. A. Terry, Shujun He, Ran Yan, Zhi Lu   +10 more
wiley   +1 more source

Comparative Immunopathology of Toxoplasma gondii Natural Infections in Marmosets (Callithrix spp.) and Howler Monkeys (Alouatta spp.), Brazil

Journal of Medical Primatology, Volume 55, Issue 5, October 2026.
ABSTRACT Introduction Neotropical primates (NTPs) present varying susceptibility to toxoplasmosis caused by Toxoplasma gondii, but their immunopathogenic responses remain poorly understood. Materials and Methods Local immune responses were characterized in the liver, spleen, and central nervous system (CNS) of 50 naturally infected NTPs (31 Callithrix ...
Marina Pellegrino, Alessandra L. M. Santos, Cinthya dos Santos Cirqueira, Gabrielle F. P. da Silva Gagliotti, Ana Carolina Ewbank, Carlos Sacristán, Rodrigo Albergaria Ressio, Natália C. C. A. Fernandes, Juliana Mariotti Guerra, José Luiz Catão‐Dias   +9 more
wiley   +1 more source

Studies on a-amylase inhibitors from seeds of sorghum bicolor [PDF]

, 1991
Six inhibitors (Slal, SIa2, SIa3, SIa4, SIa5 and SIa6) of a-amylase from mammalian, insect, bacterial and fungal sources were purified from seeds of Sorghum bicolor (L) Moench by saline extraction, precipitation with ammonium sulphate, affinity ...
Junior, Carlos Bloch
core  

Dynamic Responses of Groundwater Flow and Salt Transport to Storm Surge Inundation in Unconfined Coastal Aquifers

Geophysical Research Letters, Volume 53, Issue 17, 16 September 2026.
Abstract Storm surges severely salinize coastal aquifers, yet post‐storm subsurface hydrodynamics remain poorly understood. We investigated surge inundation in unconfined tidal aquifers, revealing that subsurface flow recovers much faster than salinity distributions.
Canhao Cai, Chengji Shen, Shichang Li, Chunhui Lu, Ling Li   +4 more
wiley   +1 more source

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]

, 2011
Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G., Brown, Elaine, Thomson, Graeme, Blake, David G., Malone, Kirk, Turner, Nicholas J., Grant, Karen, Mottram, Jeremy C., Walkinshaw, Malcolm D., Nowicki, Matthew W.   +9 more
core  

Investigating Dietary microRNA Stability and Function Using a Transgenic Milk Model With Unique microRNA Sequences

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Upon ingestion, milk extracellular vesicles (EVs) carrying bioactive cargo such as microRNAs may survive digestion and remain bioactive. Here, milk from wild‐type and transgenic cows expressing unique microRNAs was used to isolate and characterize four EV populations.
Zeinab Husseini, Nathalie Majeau, Ismail Fliss, Abderrahim Benmoussa   +3 more
wiley   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source