Results 61 to 70 of about 984,321 (234)

Exploring the cancerous nexus: the pivotal and diverse roles of USP39 in cancer development

Discover Oncology
The ubiquitin–proteasome system enables post-transcriptional protein modification and is a major pathway for the degradation of most of them in eukaryotic cells.
Yujing Chen, Jingyi Zhang, Jinfeng Yang, Jiawei Zhao, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Weijia Zhao, Siqi Chen, Xinwen Zhang, Yi Lin, Jiamin Jin   +11 more
doaj   +1 more source

Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone

Biomolecules
E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) are pivotal regulators of bone homeostasis, orchestrating osteoblast differentiation, proliferation, and osteoclast activity by controlling protein degradation and stability. This review delineates
Haotian He, Lifei Wang, Bao Xian, Yayi Xia   +3 more
doaj   +1 more source

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

ALIANZA ESTRATÉGICA UPC - USP

, 2015
La Universidad Peruana de Ciencias Aplicadas (UPC) por medio de sus carreras de Ingeniería de Software, Ingeniería de Sistemas de Información y Ciencias de la computación; firmaron un acuerdo de trabajo conjunto con la Universidad de Sao Paulo (USP). La

core   +1 more source

Knowledge Hiding by Salespeople in a B2C Context

Knowledge and Process Management, EarlyView.
ABSTRACT This study sought to explore the possible reasons why salespeople hide knowledge from customers in a business‐to‐consumer context (B2C). Based on the existing literature on knowledge hiding at the individual, organizational, and sales levels, an exploratory methodology with a qualitative approach was adopted.
Clarisse Cordeiro Medeiros Mondego, Emerson Wagner Mainardes   +1 more
wiley   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Dialogues of the university with the scholar community about education for sustainability

, 2014
O curso Diálogos da Universidade com a Comunidade Escolar sobre Educação para a Sustentabilidade foi realizado de agosto a novembro de 2013 junto a escolas rurais da rede pública de Ibiúna, São Paulo.
Ribas, Maria Aparecida Pimentel Toloza, Jacobi, Pedro Roberto, Toledo, Renata Ferraz de, Sulaiman, Samia Nascimento, Anjos, Ana Cristina Chagas dos   +4 more
core   +1 more source

DHFR-inhibitors

, 2022
Archive of DHFR-inhibitors containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875), Silvia Gervasoni (6169202), Andrea Bosin (6743129), Helen I. Zgurskaya (3093648), Attilio Vittorio Vargiu (2358538), Paolo Ruggerone (247673)   +5 more
core   +1 more source

Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation

World Journal of Surgical Oncology
Breast cancer is a prevalent malignancy worldwide, and its treatment has increasingly shifted towards precision medicine, with immunotherapy emerging as a key therapeutic strategy.
Huiyuan Yang, Tingting Sun, Zhenni Sun, Haining Wang, Dongjie Liu, Dapeng Wu, Tao Qin, Mi Zhou   +7 more
doaj   +1 more source

Therapeutic Impact of GLP‐1 Receptor Agonists on Parkinson's Disease: A Scoping Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT No disease‐modifying treatment exists for Parkinson's disease (PD). Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained attention as promising candidates for neuroprotection, given documented expression of GLP‐1 receptors within the central nervous system and the contribution of brain insulin resistance to dopaminergic ...
João Pedro Henriques, João Pedro Stringhetta Rahal, Rafael da Cunha Gomes Ribeiro, Enzo Bogucheski Ribeiro Machado, Carlos Antonio Negrato   +4 more
wiley   +1 more source