Results 51 to 60 of about 9,678 (222)
Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors
Biomolecules, 2022 Numerous studies have shown the recovery of auditory function in mouse models of genetic hearing loss following AAV gene therapy, yet translation to the clinic has not yet been demonstrated.
Edward S. A. van Beelen +10 more
doaj +1 more source
The Environmental Context and Function of Burnt-Mounds : New Studies of Irish Fulachtaí Fiadh [PDF]
, 2017 The authors acknowledge funding from The Leverhulme Trust (F/00144/AI) and assistance from a large number of individuals including; Margaret Gowen (access to sites and assistance throughout),A. Ames, H, Essex (pollen processing), S. Rouillard & R. Smith (
Bermingham, Nora +13 more
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Elastic force restricts growth of the murine utricle
eLife, 2017 Dysfunctions of hearing and balance are often irreversible in mammals owing to the inability of cells in the inner ear to proliferate and replace lost sensory receptors.
Ksenia Gnedeva +4 more
doaj +1 more source
The Tangential Nucleus Controls a Gravito-inertial Vestibulo-ocular Reflex [PDF]
, 2014 Whilst adult vertebrates sense changes in head position using two classes of accelerometer, at larval stages zebrafish lack functional semicircular canals and rely exclusively on their otolithic organs to transduce vestibular information.
Baker, Robert +9 more
core +1 more source
Labyrinthine Abnormalities on MRI in Untreated Otosclerosis: Prevalence and Clinical Relevance
The Laryngoscope, EarlyView.In untreated otosclerosis with labyrinthine symptoms, delayed 3D FLAIR MRI rarely demonstrates endolymphatic hydrops but frequently reveals blood–labyrinth barrier (BLB) disruption. BLB enhancement is spatially associated with cochlear endosteal and round window involvement and increases with the severity of the hearing loss phenotype.
Héléna Pencroffi +7 more
wiley +1 more source
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
A Rare Case of Prostatic Utricle with Crossover Vas Deferens in Children
Medicina, 2021 Background: A prostatic utricle (PU) is an unusual pathology with most patients being asymptomatic. However, approximately 29% of patients may show lower urinary tract symptoms, recurrent urinary tract infections (UTI), postvoid dribbling, urethral ...
Tsung-Heng Wu +3 more
doaj +1 more source
Journal of Systematics and Evolution, EarlyView.We present the most densely sampled phylogeny of Carex section Lupulinae to date (107 specimens) and describe herein a new cryptic species for science from the southern United States, which is locally abundant and found in well‐explored and densely populated areas. Combining DNA sequences with morphometric data obtained from 299 samples, we Demonstrate
Étienne Lacroix‐Carignan +4 more
wiley +1 more source