Results 61 to 70 of about 43,652 (215)

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. [PDF]

, 2013
The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated.
Akslen, Albino, Anissa Chikh, Antonio Costanzo, Arima, Arnoult, Avery-Kiejda, Avery-Kiejda, Azzola, Bae, Baisden, Bardeesy, Belmar-Lopez, Benchimol, Bourne, Brinck, Burford, Bártek, Catherine A. Harwood, Chan, Charlotte M. Proby, Chehab, Chipuk, Chipuk, Choi, Colombari, Daniele Bergamaschi, David Mesher, Dellavalle, Dhillon, Di Como, Dotto, el-Deiry, Fenouille, Flores, Flores, Francesca Moretti, Fukushima, Gembarska, Giovanna Chiorino, Glusac, Gomez-Monterrey, Gressner, Hameed, Harmes, Hibi, Hirao, Hocker, Hoek, Houben, Hu, Hussein, Ikawa, Irene M. Leigh, Jacobs, Ji, Kakudo, Kanner, Kanoko, Karst, Katoh, Keyes, Kilic, Knopf, Koga, Koster, Kulesz-Martin, Lassam, Leverrier, Li, Liefer, Little, MacPartlin, Mancini, Mangiulli, Manuela Graf, Marchenko, Marchini, Maria Scatolini, Massion, Matsuoka, McGregor, Merlino, Michaelis, Mihara, Mills, Moll, Morgan, Mundt, Muthusamy, Müller, Narahashi, Nemajerova, Oda, Okada, Osada, Paolo Sanza’, Perez-Losada, Petitjean, Polsky, Prince, Reis-Filho, Reis-Filho, Ribeiro-Silva, Riley, Rino Cerio, Rocca, Rocco, Rubeta N. Matin, Sakiz, Sansome, Sato, Satyamoorthy, Scatolini, Schilling, Seitz, Senoo, Senoo, Serber, Shieh, Shields, Smalley, Sparrow, Stephanie Law Pak Chong, Stretch, Suh, Tokuyasu, Tuve, Valentina Senatore, Vance, Verhaegen, Walerych, Walerych, Weiss, Westfall, Whitesell, Wäster, Yamamoto, Yamamoto, Yang, Yang, Yaziji, Zangen, Zerp   +143 more
core   +1 more source

Combining Melphalan Percutaneous Hepatic Perfusion with Ipilimumab Plus Nivolumab in Advanced Uveal Melanoma: First Safety and Efficacy Data from the Phase Ib Part of the Chopin Trial [PDF]

, 2023
T. M. L. Tong, Mark C. Burgmans, Frank M. Speetjens, Arian R. van Erkel, R.W. van der Meer, C. S. P. van Rijswijk, M. A. Jonker-Bos, C. F. M. Roozen, M. Sporrel-Blokland, Jacob Lutjeboer, Els L. van Persijn van Meerten, Chris H. Martini, R. W. M. Zoethout, Fred G. J. Tijl, Christian U. Blank, Ellen Kapiteijn   +15 more
openalex   +1 more source

Prognostic Significance of the Modified Glasgow Prognostic Score in Patients With Stage IV Melanoma Receiving Immune Checkpoint Inhibitors: A Single‐Center Retrospective Study

The Journal of Dermatology, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for malignant melanoma (MM). However, given variable response rates and potential toxicities, identifying robust biomarkers is crucial. We investigated whether the modified Glasgow Prognostic Score (mGPS) predicts treatment efficacy and toxicity in Asian patients with
Ken Horisaki, Shusuke Yoshikawa, Wataru Omata, Arata Tsutsumida, Yoshio Kiyohara   +4 more
wiley   +1 more source

Tumour progression shows decrease in PD‐L1 expression in matched metastases/primary uveal melanomas

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICI) have revolutionised the treatment of several malignancies. However, the results of ICI therapy remain unsatisfactory in metastatic uveal melanoma (UM). We analysed the expression of PD1, PD‐L1, T‐cell and macrophage markers in a set of matched primary and metastatic UM in an attempt to better ...
Maria Chiara Gelmi, Gulçin Gezgin, Ellen Kapiteijn, T. H. Khanh Vu, Martine J. Jager, Robert M. Verdijk   +5 more
wiley   +1 more source

Prognostic analysis of uveal melanoma based on the characteristic genes of M2-type macrophages in the tumor microenvironment

BMC Bioinformatics, 2023
Uveal melanoma arises from stromal melanocytes and is the most prevalent primary intraocular tumor in adults. It poses a significant diagnostic and therapeutic challenge due to its high malignancy and early onset of metastases. In recent years, there has
Li Fu, Qun Huang, Yongfeng Wu, Diang Chen   +3 more
doaj   +1 more source

Metastatic potential of small posterior uveal melanomas

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the prevalence of aggressive traits in small posterior uveal melanomas (UM). Methods This retrospective, multicentre cohort study included 804 patients with small posterior UM (≤9 mm in largest basal diameter, ≤3 mm in thickness) from centres in the UK, Germany, and Sweden.
Gustav Stålhammar, Helen Kalirai, Sarah E. Coupland, Salvatore Grisanti, Svenja Rebecca Sonntag, Ayseguel Tura, Antonio Eleuteri, Rumana N. Hussain, Heinrich Heimann, Hannah Coudé Adam   +9 more
wiley   +1 more source

Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors

Nature Communications, 2018
Hypermutated tumors respond more favorably to checkpoint inhibitor-based immune therapy. Here, the authors describe a new hypermutated phenotype due to germline mutations and subsequent somatic loss of heterozygosity of MBD4, and a dramatic response to ...
Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice Fiévet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, Stéphane Dayot, Virginie Raynal, Michèle Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, François-Clément Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern   +21 more
doaj   +1 more source

Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma [PDF]

, 2015
AIMS: The aim of the present study was to immunohistochemically investigate the expression and prognostic significance of putative cancer stem cell markers CD117 (c-kit), CD34, CD20 and CD15 in a cohort of patients with primary choroidal and ciliary ...
Dotlić, Snježana, Lukenda, Adrian, Vranić, Semir, Vukojević, Nenad, Šarić, Borna, Žarković, Kamelija   +5 more
core   +1 more source

Tumor Profiles of Late Presentation Uveal Ring Melanoma With Novel Characteristics – A Case Series [PDF]

, 2023
Joevy Lim, Alexandra Z. Crawford, Charles N. J. McGhee   +2 more
openalex   +1 more source

Malignant craniopharyngiomas: Institutional experience and literature review

Brain Pathology, EarlyView.
We report the second case of malignant craniopharyngioma with BAP1 and TP53 mutations. A literature review identified 44 cases of malignant craniopharyngiomas with a median overall survival of 6 months. Eighteen (41%) occurred in patients without any history of radiation, suggesting that mechanisms other than radiation have contributed to their ...
Thomas J. Auen, Isabella W. Zhang, Weiwei Zhang, Jordan M. Burr, Matthew L. Carda, James L. Wisecarver, Nicole Shonka, Jesse L. Cox, Sahara J. Cathcart, Allison Cushman‐Vokoun, Jie Chen   +10 more
wiley   +1 more source