Results 1 to 10 of about 156,233 (327)

Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function. [PDF]

PLoS ONE, 2012
The vacuolar proton-pumping ATPase (V-ATPase) is the main mediator of intracellular organelle acidification and also regulates transmembrane proton (H(+)) secretion, which is necessary for an array of physiological functions fulfilled by organs such as ...
Teodor G Păunescu, Steven Rodriguez, Eric Benz, Mary McKee, Robert Tyszkowski, Mark W Albers, Dennis Brown   +6 more
doaj   +22 more sources

V-ATPase-dependent induction of selective autophagy [PDF]

Nature Communications
The general consensus is that the vacuolar-type H+-translocating ATPase (V-ATPase) is critical for macroautophagy/autophagy. However, there is a fundamental conundrum because follicular lymphoma-associated mutations in the V-ATPase result in lysosomal ...
Yuxiang Huang, Dimitra Dialynaki, Yuchen Lei, Zhihai Zhang, Charles R. Evans, Daniel J. Klionsky   +5 more
doaj   +2 more sources

V-ATPase Dysfunction in the Brain: Genetic Insights and Therapeutic Opportunities [PDF]

Cells
Vacuolar-type ATPase (v-ATPase) is a multimeric protein complex that regulates H+ transport across membranes and intra-cellular organelle acidification. Catabolic processes, such as endocytic degradation and autophagy, strictly rely on v-ATPase-dependent
Antonio Falace, Greta Volpedo, Marcello Scala, Federico Zara, Pasquale Striano, Anna Fassio   +5 more
doaj   +2 more sources

V-ATPase in cancer: mechanistic insights and therapeutic potentials [PDF]

Cell Communication and Signaling
Vacuolar-type H+-ATPase (V-ATPase) is a crucial proton pump that plays an essential role in maintaining intracellular pH homeostasis and a variety of physiological processes.
Tingting Chen, Xiaotan Lin, Shuo Lu, Bo Li   +3 more
doaj   +2 more sources

V-ATPase in glioma stem cells: a novel metabolic vulnerability [PDF]

Journal of Experimental & Clinical Cancer Research
Background Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity.
Alessandra Maria Storaci, Irene Bertolini, Cristina Martelli, Giorgia De Turris, Nadia Mansour, Mariacristina Crosti, Maria Rosaria De Filippo, Luisa Ottobrini, Luca Valenti, Elisa Polledri, Silvia Fustinoni, Manuela Caroli, Claudia Fanizzi, Silvano Bosari, Stefano Ferrero, Giorgia Zadra, Valentina Vaira   +16 more
doaj   +2 more sources

V-ATPase C Acts as a Receptor for Bacillus thuringiensis Cry2Ab and Enhances Cry2Ab Toxicity to Helicoverpa armigera [PDF]

Insects
Cry2Ab is a significant alternative Bacillus thuringiensis (Bt) protein utilized for managing insect resistance to Cry1 toxins and broadening the insecticidal spectrum of crops containing two or more Bt genes. Unfortunately, the identified receptors fail
Pin Li, Yuge Zhao, Ningbo Zhang, Xue Yao, Xianchun Li, Mengfang Du, Jizhen Wei, Shiheng An   +7 more
doaj   +2 more sources

TBC1D24 interacts with the v-ATPase and regulates intraorganellar pH in neurons [PDF]

iScience
Summary: The vacuolar ATPase (v-ATPase) is essential for acidification of intracellular organelles, including synaptic vesicles. Its activity is controlled by cycles of association and dissociation of the ATP hydrolysis (V1) and proton transport (V0 ...
Sara Pepe, Davide Aprile, Enrico Castroflorio, Antonella Marte, Simone Giubbolini, Samir Hopestone, Anna Parsons, Tânia Soares, Fabio Benfenati, Peter L. Oliver, Anna Fassio   +10 more
doaj   +2 more sources

CLC3 regulates V-ATPase to enhance lysosomal degradation and cisplatin resistance in cervical cancer cells [PDF]

Cell Death Discovery
Chemoresistance remains a major challenge in cervical cancer (CVC) treatment. Lysosomal function, mediated by V-ATPase, is critical in cancer progression and drug resistance. CLC3, a chloride channel that regulates lysosomal acidification, may contribute
Chuyun Chen, Fubin Zhang, Jiayi Shen, Qi Zheng, Zhiyun Zhang, Shun Lu, Lixiao Liu, Tianhong Zhu, Yongming Du, Yutao Guan   +9 more
doaj   +2 more sources

V-ATPase and Lysosomal Energy Sensing in Periodontitis and Medicine-Related Osteonecrosis of the Jaw. [PDF]

Biomolecules
Yang X, Holliday LS.
europepmc   +3 more sources

Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts

Disease Models & Mechanisms, 2021
The vacuolar-type H+-ATPase (V-ATPase) is a multi-subunit proton pump that regulates cellular pH. V-ATPase activity modulates several cellular processes, but cell-type-specific functions remain poorly understood.
Peu Santra, Jeffrey D. Amack
doaj   +1 more source