Frontiers in Plant Science, 2022 V-ATPase is the dominant proton pump in plant cells. It contributes to cytosolic pH homeostasis and energizes transport processes across endomembranes of the secretory pathway.
Thorsten Seidel
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Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function. [PDF]
PLoS ONE, 2012 The vacuolar proton-pumping ATPase (V-ATPase) is the main mediator of intracellular organelle acidification and also regulates transmembrane proton (H(+)) secretion, which is necessary for an array of physiological functions fulfilled by organs such as ...
Teodor G Păunescu +6 more
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The evolutionary conserved TLDc domain defines a new class of (H+)V-ATPase interacting proteins
Scientific Reports, 2021 We recently found that nuclear receptor coactivator 7 (Ncoa7) and Oxr1 interact with the proton-pumping V-ATPase. Ncoa7 and Oxr1 belong to a group of proteins playing a role in the oxidative stress response, that contain the conserved “TLDc” domain. Here
A. F. Eaton, D. Brown, M. Merkulova
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Structure and topography of the synaptic V-ATPase-synaptophysin complex. [PDF]
NatureSynaptic vesicles are organelles with a precisely defined protein and lipid composition1,2, yet the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown.
Wang C +16 more
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V-ATPase-dependent induction of selective autophagy [PDF]
Nature CommunicationsThe general consensus is that the vacuolar-type H+-translocating ATPase (V-ATPase) is critical for macroautophagy/autophagy. However, there is a fundamental conundrum because follicular lymphoma-associated mutations in the V-ATPase result in lysosomal ...
Yuxiang Huang +5 more
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Reciprocal Regulation of V-ATPase and Glycolytic Pathway Elements in Health and Disease
Frontiers in Physiology, 2019 The ability of cells to adapt to fluctuations in glucose availability is crucial for their survival and involves the vacuolar proton-translocating ATPase (V-ATPase), a proton pump found in all eukaryotes.
Summer R. Hayek +2 more
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Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids
Frontiers in Cell and Developmental Biology, 2020 Luminal pH and the distinctive distribution of phosphatidylinositol phosphate (PIP) lipids are central identifying features of organelles in all eukaryotic cells that are also critical for organelle function.
Subhrajit Banerjee, Patricia M. Kane
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V-ATPase Dysfunction in the Brain: Genetic Insights and Therapeutic Opportunities [PDF]
CellsVacuolar-type ATPase (v-ATPase) is a multimeric protein complex that regulates H+ transport across membranes and intra-cellular organelle acidification. Catabolic processes, such as endocytic degradation and autophagy, strictly rely on v-ATPase-dependent
Antonio Falace +5 more
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V-ATPase in cancer: mechanistic insights and therapeutic potentials [PDF]
Cell Communication and SignalingVacuolar-type H+-ATPase (V-ATPase) is a crucial proton pump that plays an essential role in maintaining intracellular pH homeostasis and a variety of physiological processes.
Tingting Chen +3 more
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V-ATPase in glioma stem cells: a novel metabolic vulnerability [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity.
Alessandra Maria Storaci +16 more
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