Results 111 to 120 of about 3,831 (231)

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Comparisons of vaborbactam-bound PBP3 with the P. aeruginosa PBP3-β-lactam, monobactam, and DBO complexes.

, 2021
A, vaborbactam-bound PBP3 structure with ligand in ball-and-stick representation with cyan-colored carbon atoms. The ligand’s oxygen located in the oxyanion hole (a), the carboxyl (b), the amide (c), and the five-membered thiophene (d) are labeled.
Vijay Kumar (377076), Jeeda Ismail (11570566), Focco van den Akker (158508), Shreya Agarwal (774270), Samantha L. Viviani (11570563), Robert A. Bonomo (188763)   +5 more
core   +1 more source

Meropenem/vaborbactam: a next generation β-lactam β-lactamase inhibitor combination [PDF]

, 2020
Andrea Novelli, Paola Del Giacomo, Gian María Rossolini, Mario Tumbarello   +3 more
openalex   +1 more source

Activity of ceftazidime/avibactam, meropenem/vaborbactam and imipenem/relebactam against carbapenemase-negative carbapenem-resistant Enterobacterales isolates from US hospitals

, 2021
Mariana Castanheira, Timothy B Doyle, Lalitagauri M. Deshpande, Rodrigo E. Mendes, Hélio S. Sader   +4 more
openalex   +1 more source

Meropenem-vaborbactam: a critical positioning for the management of infections by Carbapenem-resistant Enterobacteriaceae

, 2022
Introduction: The review aims to review the positioning of meropenem-vaborbactam in clinical practice, taking into consideration the characteristics of other available drugs, namely ceftazidime-avibactam, plazomicin, and colistin.
Giamarellos-Bourboulis, E.J., Mouktaroudi, M., Kotsaki, A.   +2 more
core  

Continuous infusion of meropenem–vaborbactam for a KPC-3-producing Klebsiella pneumoniae bloodstream infection in a critically ill patient with augmented renal clearance

, 2023
International audienceAbstract Purpose To demonstrate the feasibility of continuous infusion of meropenem–vaborbactam to optimize the treatment of carbapenem-resistant Enterobacterales.
Larcher, Romaric, Cléa Gandon, Alix Pantel, Naciri, Tayma, Pantel, Alix, Sotto, Albert, Paul Laffont-Lozes, Magnan, Chloé, Albert Sotto, Bourgeois, Pierre-Marie, Chloé Magnan, Tayma Naciri, Laffont-Lozes, Paul, Gandon, Cléa, Romaric Larcher, Pierre-Marie Bourgeois   +15 more
core   +1 more source

Simultaneous post-neurosurgical ventriculitis and bacteraemia by two different strains of KPC-producing K. pneumoniae successfully treated with meropenem/vaborbactam and high dose of fosfomycin

Journal of Global Antimicrobial Resistance
Objective: A case of post-neurosurgical ventriculitis caused by a KPC-producing Klebsiella pneumoniae (KPC-Kp) with a ceftazidime/avibactam-resistant, meropenem-susceptible phenotype is reported.
Lorenzo Volpicelli, Sara Cairoli, Dania Al Ismail, Floriana Baisi, Federica Sacco, Bianca Maria Goffredo, Mario Venditti, Alessandra Oliva   +7 more
doaj   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2485-2489, September 2025.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

VALIDATION OF SIMPLE ISOCRATIC RP-UPLC METHOD FOR MEROPENEM AND VABORBACTAM DETERMINATION AND IT'S APPLICATION IN THE STUDY OF STRESS DEGRADATION

, 2018
A simple, Accurate, precise method was developed for the simultaneous estimation of the Meropenem and Vaborbactam in tablet dosage form. Chromatogram was run through SB C8 100 x 3.0 mm, 1.8m.
Sudha Rani Bollimuntha 1 *, Kalyana Seela Kottapalli 2, Bhavya Manda 3
core   +1 more source

Susceptibility evaluation of novel beta-lactam/beta-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae from bloodstream infections in hospitalized patients in Brazil

Journal of Global Antimicrobial Resistance
Introduction: Novel beta-lactam/beta-lactamase inhibitor (BIBLI) combinations are commercially available and have been used for treating carbapenem-resistant Klebsiella pneumoniae (CRKP) infections.
Camila Mörschbächer Wilhelm, Laura Czerkster Antochevis, Cibele Massotti Magagnin, Beatriz Arns, Tarsila Vieceli, Dariane Castro Pereira, Larissa Lutz, Ândrea Celestino de Souza, Jéssica Nesello dos Santos, Rafaela Ramalho Guerra, Gregory S. Medeiros, Lucas Santoro, Diego R. Falci, Maria Helena Rigatto, Afonso Luís Barth, Andreza Francisco Martins, Alexandre Prehn Zavascki   +16 more
doaj   +1 more source