Results 111 to 120 of about 4,565 (213)

Activity of Aztreonam-avibactam and other β-lactamase inhibitor combinations against Gram-negative bacteria isolated from patients hospitalized with pneumonia in United States medical centers (2020–2022)

BMC Pulmonary Medicine
Background Initial antimicrobial therapy for pneumonia is frequently empirical and resistance to antimicrobial agents represents a great challenge to the treatment of patients hospitalized with pneumonia.
Helio S. Sader, Rodrigo E. Mendes, S. J. Ryan Arends, Timothy B. Doyle, Mariana Castanheira   +4 more
doaj   +1 more source

Flow cytometry enables rapid evaluation of novel, new and niche antimicrobial agents

Frontiers in Microbiology
The global rise of multidrug-resistant bacteria necessitates the development of new antimicrobials and faster diagnostic tools. Conventional antimicrobial susceptibility testing is slow, relying on culture-based methods that delay effective treatment ...
Emily Salisbury, Emily Salisbury, Kieran Mulroney, Kieran Mulroney, Malgorzata K. Kopczyk, Malgorzata K. Kopczyk, Teagan Paton, Teagan Paton, Christine F. Carson, Wai Shaun Ho, Wai Shaun Ho, Aron Chakera, Aron Chakera, Aron Chakera   +13 more
doaj   +1 more source

New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Lung Transplantation: Clinical Evidence, Safety, and PK/PD Properties

Transplant International
Infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB) and Pseudomonas aeruginosa are leading causes of morbidity and mortality after lung transplantation (LuTx).
Andrea Lombardi, Andrea Lombardi, Davide Mangioni, Giulia Viero, Laura Alagna, Giulia Renisi, Paola Saltini, Alessandra Bandera, Alessandra Bandera   +8 more
doaj   +1 more source

A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia [PDF]

Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge.
Cascio, Antonio, Giammanco, Giovanni Maurizio, Iacopino, Domenico Gerardo, Maugeri, Rosario, Pipitò, Luca, Rubino, Raffaella, Santoro, Marco, Siragusa, Sergio, Sucato, Giuseppe, Trizzino, Marcello   +9 more
core   +1 more source

Resistance to Ceftazidime/Avibactam, Meropenem/Vaborbactam and Imipenem/Relebactam in Gram-Negative MDR Bacilli: Molecular Mechanisms and Susceptibility Testing [PDF]

, 2022
Coppi, Marco, Giani, Tommaso, Rossolini, Gian Maria   +2 more
core   +1 more source

Diagnostic algorithm for the detection of carbapenemases and extended-spectrum β-lactamases in carbapenem-resistant Pseudomonas aeruginosa [PDF]

Pseudomonas aeruginosa can acquire carbapenem resistance through various mechanisms, including genomic mutations leading to the overexpression of efflux pumps, intrinsic AmpC-β-lactamase, and/or reduced permeability, and/or through the acquisition of ...
Egli, Adrian, Garcia-Verellen, Laia, Hinic, Vladimira, Keller, Peter M, Kolesnik-Goldmann, Natalia, Mancini, Stefano, Nolte, Oliver, Roloff, Tim, Seth-Smith, Helena M B, Syed, Muhammad Ali, Ullah, Irfan   +10 more
core   +1 more source

Antimicrobial susceptibility of clinically important carbapenem-resistant Enterobacterales towards standard and new antibiotics

Journal of Global Antimicrobial Resistance
AIM: The aim of this work is to study carbapenem-resistant Enterobacterales (CRE) incidence, carbapenemase types and antimicrobial susceptibility of the strains to standard and new antibiotics.
Deniz Hamidov, Emma Keuleyan, Theodor Todorov, Radoslava Vazharova, Georgi Todorov, Atanas Syarov   +5 more
doaj   +1 more source

Using fragment-based approaches to discover new antibiotics [PDF]

, 2018
Hubbard, Roderick Eliot, Lamoree, Bas
core   +1 more source

Boronate-Based Inhibitors of Penicillin-Binding Proteins: An Underestimated Avenue for Antibiotic Discovery? [PDF]

Penicillin-binding proteins (PBPs) are essential enzymes involved in bacterial cell wall biosynthesis and represent the primary targets of β-lactam antibiotics.
Emilia Caselli, Fabio Prati, Luca Svolacchia Brusoni, Nicolo Santi, Valentina Villamil   +4 more
core   +1 more source

Meropenem–Vaborbactam for the Treatment of Post-Neurosurgical Meningitis Caused by KPC Producer Klebsiella Pneumoniae: A Case Report and Review of the Literature

Antibiotics
Meningitis and ventriculitis, due to carbapenem-resistant Enterobacterales, are frequently associated with significant morbidity and mortality. In the case of multi-drug-resistant pathogens, it is necessary to consider the limited susceptibility profile ...
Leonardo Francesco Rezzonico, Francesco Peracchi, Marta Vecchi, Gabriele Bassi, Marco Merli, Nicholas Brian Bana, Giovanna Travi, Fulvio Crippa, Massimo Puoti   +8 more
doaj   +1 more source