Results 111 to 120 of about 495,603 (297)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Rapid determination of influenza vaccine potency by an SPR-based method using subtype or lineage-specific monoclonal antibodies. [PDF]

Front Immunol, 2023
Narayan K, Paduraru C, Blake T, Arunachalam AB.   +3 more
europepmc   +1 more source

Antibody signatures elicited by potent and subpotent whole-cell pertussis vaccines in mice

Microbiology Spectrum
Inactivated, whole-cell pertussis (wP) vaccines remain at the frontline in the global fight against the resurgence of whooping cough, especially in low- and middle-income countries. However, the reliance on the intracerebral mouse potency test (ic-MPT or
Yetunde Adewunmi, Jennifer Doering, Prashant Kumar, Jozelyn V. Pablo, Andy A. Teng, Vu Huynh, Kathryn Secrist, David B. Volkin, Sangeeta B. Joshi, Joseph J. Campo, Nicholas J. Mantis   +10 more
doaj   +1 more source

Socioeconomic inequalities in completion of hepatitis B vaccine series among Korean women: results from a nationwide interview survey

, 2012
BACKGROUND: Hepatitis B virus (HBV) infection and its sequelae are major global health problems. This study was conducted to investigate the association between factors related to socioeconomic status and HBV vaccination in the general population of ...
박은철
core  

Household survey of hepatitis B vaccine coverage among Brazilian children

, 2009
We conducted a multi-stage household cluster survey to calculate hepatitis B vaccine coverage among children 18-30 months of age in 27 Brazilian cities.
FLANNERY, Brendan, Vaccine Coverage Survey 2007 Grp, LUNA, Expedito J. A., MORAES, Jose Cassio de, VERAS, Maria Amelia S. M.   +4 more
core   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency. [PDF]

Vaccine, 2022
McAdams D, Estrada M, Holland D, Singh J, Sawant N, Hickey JM, Kumar P, Plikaytis B, Joshi SB, Volkin DB, Sitrin R, Cryz S, White JA.   +12 more
europepmc   +1 more source

Stability study of recombinant 9-valent human papillomavirus vaccine based on Escherichia coli expression system

Human Vaccines & Immunotherapeutics
This study reports on the long-term stability of a recombinant 9-valent HPV vaccine, addressing a gap in the literature as previous research did not extend beyond 72 months.
Yuying Liu, Dan Chen, Li Zhao, Haijiang Zhang, Shuming Wu, Xiao Chen, Ercui Shen, Ling Li, Zengmin Yang, Yan Wang, Fei Yin, Yao Zhang, Yazheng Shi, Shuyi Zhou, Shuang Li, Xiaoli Du, Jiaping Guo, Di Wang, Huan Wang, Shujuan Liu, Guiying Jin, Hongcai Zhang, Xinyu Yu, Xuejiao Chen, Lulu Shang, Yang Liu, Yongjiang Liu   +26 more
doaj   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Ensuring vaccine potency and availability: how evidence shaped Gavi's Immunization Supply Chain Strategy. [PDF]

BMC Health Serv Res, 2022
Prosser W, Sagar K, Seidel M, Alva S.
europepmc   +1 more source