Results 101 to 110 of about 495,603 (297)

Incidence of narcolepsy before and after MF59-adjuvanted influenza A(H1N1)pdm09 vaccination in South Korean soldiers

, 2015
BACKGROUND: Previous reports mostly from Europe suggested an association between an occurrence of narcolepsy and an influenza A(H1N1)pdm09 vaccine adjuvanted with AS03 (Pandemrix(®)).
이은, 남궁기
core   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine

, 2013
[[abstract]]AbstractBackground Large-scale outbreaks of enterovirus 71 (EV71) infections have occurred in Asia-Pacific regions. Severe complications include encephalitis and poliomyelitis-like paralysis, cardiopulmonary collapse, and death, necessitating
Cheng, A;Fung, CP;Liu, CC;Lin, YT;Tsai, HY;Chang, SC;Chou, AH;Chang, JY;Jiang, RH;Hsieh, YC;Su, IJ;Chong, PCS;Hsieh, SM
core   +1 more source

Isolation and identification of Klebsiella pneumoniae from Tibetan pigs and preparation of inactivated vaccine with Tibetan medicine adjuvant

BMC Veterinary Research
This study investigated the prevalence of Klebsiella pneumoniae (KP) in Tibetan pigs. Nasal swabs and lung tissue samples were collected, from which hypervirulent Klebsiella pneumoniae (hvKP) were isolated through culture, identification, serotyping, and
Gang Wang, Yanjuan Zhao, Xiaoxia Ye, Runbo Luo, Mingbang Wei, Hongliang Zhang, Jian Zhang, Peng Shang   +7 more
doaj   +1 more source

Evaluation of Thimerosal on the Potency and Stability of Inactivated Animal Rabies Vaccine [PDF]

, 2019
Thimerosal is used as a preservative in Rabies vaccine. This study aimed at comparing potency and stability of inactivated animal rabies vaccine with and without thimerosal. Therefore, two groups of rabies vaccine were produced.
Chehrazi, Mohammad, Moradi-Joshaghan, Ali, Ahmadnejad, Farzaneh, Jodairi Eslami, Saeed, Miandehi, Nargess, Parhizkar, Zohreh, Gholami, Alireza, Roshanaei, Bahram   +7 more
core   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Immunogenicity, Efficacy and Twelve-Month Storage Stability Studies of a Lyophilized Rabies mRNA Vaccine

Vaccines
Background: Many new mRNA-based vaccine candidates in liquid mRNA-LNP formulations are under development; however, their stability limitations necessitate frozen storage, posing a significant challenge for long-term storage and transportation.
Chen Chen, Dandan Ling, Kai Ji, Liang Tang, Xiaojing Zhang, Xishan Lu, Xuemei Leng, Changyao Tan, Hongchao Wu, Wenqiang Pang, Quanren He, Jerry Zhang, Peng Gao, Xiaotao Wang, Linhui Wang, Bo Ying   +15 more
doaj   +1 more source

Explanations for the high potency of HPV prophylactic vaccines

Vaccine, 2018
HPV L1 virus-like particle (VLP) vaccines administered in a prime/boost series of three injections over six months have demonstrated remarkable prophylactic efficacy in clinical trials and effectiveness in national immunization programs with high rates of coverage.
Schiller, John, Lowy, Doug
openaire   +2 more sources

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Replacement of in vivo leptospirosis vaccine potency testing in the United States. [PDF]

Biologicals, 2022
Rogers B, Brown J, Allen DG, Casey W, Clippinger AJ.   +4 more
europepmc   +1 more source