Results 81 to 90 of about 495,603 (297)

Efficacy Of Lyophilized Inactivated Rabies Vaccine

Journal of Applied Veterinary Sciences, 2020
An interesting finding that emerged from the study was the difference in potency between inactivated rabies vaccines prepared in liquid and lyophilized forms.
Omaima A. A. Alshamandy, Heba M. G. Abd El-Aziz   +1 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Investigating the impact of oxygen concentration on the assembly of human papillomavirus virus like particles

Scientific Reports
In HPV vaccine production, the thermal stability, particulate morphology, homogeneity, and immunogenicity of virus-like particles (VLPs) are critical for vaccine efficacy.
Yuying Liu, Dan Chen, Wenshuang Gao, Ercui Shen, Xiao Chen, Xiaoli Du, Di Wang, Shuyi Zhou, Hongcai Zhang, Xinyu Yu, Yongjiang Liu   +10 more
doaj   +1 more source

The evaluation of the possibility of the estimation the amount of hemagglutininin in the final lots of inactivated adjuvanted influenza vaccines

Вопросы вирусологии
Introduction. The main quality indicator for inactivated influenza vaccines is their potency (the amount of hemagglutinin). The potency test for the influenza vaccine with the SOVIDON adjuvant is carried out in a trivalent bulk vaccine before the ...
Aleksey Y. Butirskiy, Elena N. Morozova, Karine A. Sarkisyan   +2 more
doaj   +1 more source

Characteristics of serology-based vaccine potency models for foot-and-mouth disease virus.

, 2012
<p><b>BACKGROUND: </b>Foot-and-mouth disease (FMD) vaccine potency testing involves hundreds of animals each year. Despite considerable efforts during the past decades, a challenge-free alternative vaccine potency test to replace the ...
B. Haas, P. Guntram, Paul, G., V.I. Diev, N. Goris, Lefebvre, D.J., T. Willems, S.R. Kremenchugskaya, Diev, V.I., D. Lefebvre, Goris, N., De Clercq, K., Willems, T., Kremenchugskaya, S.R., K. De Clercq, Haas, Bernd   +15 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Immunogenicity of monovalent and multivalent subunit vaccines against SARS-CoV-2 variants in mice with divergent vaccination history

Microbiology Spectrum
There are challenges in selecting SARS-CoV-2 vaccine compositions, primarily due to divergent infection or vaccination history and immunological biases toward previous strains. In this study, we evaluated humoral immune responses induced by variant-based
Rui Wang, Yuan Lyu, Meng Chen, Lili Sun, Shaozheng Zhou, Yudi Cui, Juan Ma, Desheng Kong, Jianbo Lu, Xuefeng Li, Liangzhi Xie   +10 more
doaj   +1 more source

Identification and characterization of a cross-neutralization epitope of Enterovirus 71

, 2012
[[abstract]]Enterovirus 71 (EV71) infections in children manifest as exanthema and are most commonly known as hand-foot-and-mouth disease (HFMD). Because it can cause severe neurological complications like poliomyelitis, EV71 has now emerged as an ...
Liu, CC;Chou, AH;Lien, SP;Lin, HY;Liu, SJ;Chang, JY;Guo, MS;Chow, YH;Yang, WS;Chang, KH;Sia, C;Chong, P
core   +1 more source

Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis

Advanced Materials, EarlyView.
Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne, Julian S. Hertel, André Delavault, Judith Felk, Martin Peng, Lara Reuber, Felix Ott, Kim Wanner, Marc F. Münker, Adrian Neukirch, Alexei Kiselev, Kersten S. Rabe, Christof M. Niemeyer   +12 more
wiley   +1 more source

Wavelength‐Multiplexed 2D Beam Steering via a Passive Diffractive Network

Advanced Optical Materials, EarlyView.
Illustration of a wavelength‐multiplexed diffractive beam steering system, which is composed of K cascaded diffractive layers, each containing phase‐modulating elements that are jointly optimized using deep learning–based optimization. When illuminated with a set of wavelengths {λ1,λ2,…,λNw}$\{ {{{\lambda }_1},{{\lambda }_2},\ldots ,{{\lambda }_{{{N}_w}
Che‐Yung Shen, Yuhang Li, Çağatay Işıl, Tianyi Gan, Mona Jarrahi, Aydogan Ozcan   +5 more
wiley   +1 more source