Results 31 to 40 of about 1,439,979 (204)

Rational Development of Live-Attenuated Zika Virus Vaccines

Pathogens, 2023
Zika virus (ZIKV), a re-emerging mosquito-borne flavivirus, has caused outbreaks in Africa, Asia, the Pacific, and, more recently, in the Americas. ZIKV has been associated with the neurological autoimmune disorder Guillain–Barre syndrome in adults and ...
Awadalkareem Adam, Christy Lee, Tian Wang   +2 more
doaj   +1 more source

Novel Approaches for The Development of Live Attenuated Influenza Vaccines

Viruses, 2019
Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines.
P. Blanco-Lobo, A. Nogales, Laura Rodríguez, L. Martínez-Sobrido   +3 more
semanticscholar   +1 more source

New Points of Departure for More Global Influenza Vaccine Use

Vaccines, 2020
Each year, influenza causes a significant acute respiratory disease burden. In addition, influenza pandemics periodically occur. Annual vaccination is the best tool for influenza prevention, but its effectiveness can vary from year to year.
Irina Kiseleva
doaj   +1 more source

Comparison of the efficacy of autogenous inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccines with that of commercial vaccines against homologous and heterologous challenges

BMC Veterinary Research, 2012
Background The porcine reproductive and respiratory syndrome virus (PRRSV) is a rapidly evolving pathogen of swine. At present, there is a high demand for safe and more effective vaccines that can be adapted regularly to emerging virus variants. A recent
Geldhof Marc F, Vanhee Merijn, Van Breedam Wander, Van Doorsselaere Jan, Karniychuk Uladzimir U, Nauwynck Hans J   +5 more
doaj   +1 more source

Current status of vaccine research, development, and challenges of vaccines for Mycoplasma gallisepticum

Poultry Science, 2020
Mycoplasma gallisepticum (MG) is an important avian pathogen that causes significant economic losses in the poultry industry. Surprisingly, the limited protection and adverse reactions caused by the vaccines, including live vaccines, bacterin-based ...
Muhammad Ishfaq, Wanying Hu, Mohammad Zeb Khan, Ijaz Ahmad, Wenxin Guo, Jichang Li   +5 more
doaj   +1 more source

Blood B Cell Depletion Reflects Immunosuppression Induced by Live-Attenuated Infectious Bursal Disease Vaccines

Frontiers in Veterinary Science, 2022
Immunosuppression in poultry production is a recurrent problem worldwide, and one of the major viral immunosuppressive agents is Infectious Bursal Disease Virus (IBDV). IBDV infections are mostly controlled by using live-attenuated vaccines.
Céline Courtillon, Chantal Allée, Michel Amelot, Alassane Keita, Stéphanie Bougeard, Sonja Härtle, Jean-Claude Rouby, Nicolas Eterradossi, Sebastien Mathieu Soubies   +8 more
doaj   +1 more source

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

Nature Microbiology, 2023
Comparison of mucosal and systemic immunity after vaccination with the live-attenuated vaccine sCPD9, mRNA vaccine BNT162b2 or an adenovirus-vectored vaccine following SARS-CoV-2 challenge in hamsters. Vaccines play a critical role in combating the COVID-
G. Nouailles, J. Adler, P. Pennitz, Stefan Peidli, L. T. Teixeira Alves, Morris Baumgardt, J. Bushe, A. Voss, A. Langenhagen, Christine Langner, Ricardo Martin Vidal, F. Pott, J. Kazmierski, Aileen Ebenig, Mona V. Lange, M. D. Mühlebach, C. Goekeri, S. Simmons, Na Xing, Azza Abdelgawad, S. Herwig, G. Cichon, Daniela Niemeyer, C. Drosten, C. Goffinet, M. Landthaler, N. Blüthgen, Haibo Wu, M. Witzenrath, A. Gruber, Samantha D. Praktiknjo, N. Osterrieder, E. Wyler, Dusan Kunec, Jakob Trimpert   +34 more
semanticscholar   +1 more source

A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study

Vaccines, 2018
Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains.
Raffael Nachbagauer, F. Krammer, R. Albrecht   +2 more
semanticscholar   +1 more source

Mucosal vaccines — fortifying the frontiers

Nature reviews. Immunology, 2021
Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. In principle, the induction of adaptive immunity at mucosal sites, involving secretory antibody responses and tissue ...
E. Lavelle, Ross W. Ward
semanticscholar   +1 more source

LC16m8: An attenuated smallpox vaccine

Vaccine, 2006
The frequency of moderate to severe adverse reactions associated with smallpox vaccines currently stockpiled in the US, and the continued threat of bioterrorism have prompted the development of effective vaccines with improved safety profiles. LC16m8, an attenuated, replicating smallpox vaccine derived from the Lister strain of vaccinia, is currently ...
Kenner, Julie, Cameron, Fiona, Empig, Cyril, Jobes, David V., Gurwith, Marc   +4 more
openaire   +2 more sources