Results 91 to 100 of about 2,619,226 (251)

Fort Leavenworth master development plan.

, 2016
Fort Leavenworth's history is a tradition of growth to meet changing mission requirements. The oldest and newest construction reflects efforts to insure that Fort Leavenworth is capable of meeting these requirements.
Combined Arms Center and Fort Leavenworth
core  

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Advances in the application of tumor vaccines and combination strategies: new perspectives in lung cancer treatment

Frontiers in Immunology
Lung cancer remains one of the most prevalent and lethal malignancies globally and its treatment has consistently been a focal point of research in the medical field. The emergence of immunotherapies such as immune checkpoint inhibitors has brought about
Lei Sun, Qi Zhao, Liyun Miao
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Immunogenicity and reactogenicity following primary immunization with a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine and Haemophilus influenzae type b conjugate vaccine administered by separate or mixed injection

, 2005
The aim of this open, randomised, multicentre trial was to evaluate the immunogenicity and reactogenicity of the tetravalent diphtheria-tetanus-acellular pertussis-hepatitis B (DTaP-HBV) vaccine when given either as a mixed or as a separate concomitant ...
GABUTTI, Giovanni, CROVARI P, BAMFI F, MAJORI S, BONA G, HARDT K, THE COOPERATIVE GROUP FOR THE STUDY OF COMBINED VACCINES, DENTICO P   +7 more
core  

Feasibility analysis and study on immune effects of combined immunization with mixed inactivated vaccines in chickens

Journal of Applied Poultry Research
Summary: Combination immunization offers several benefits, such as reducing vaccination frequency, minimizing stress responses, and lowering labor costs.
Linguo Wang, Lingyan Jiang, Tao Zhu, Feng Wang, Guangjin Lin   +4 more
doaj   +1 more source

Efficacy of an inactivated bivalent Rabbit Hemorrhagic Disease Virus 2 – Pasteurellosis vaccine in Rabbits by using a new Adjuvant. [PDF]

Benha Veterinary Medical Journal
Rabbit production is an important investment in the animal sector.The purpose of this study is to prepare an efficient vaccine combating Rabbit Hemorrhagic Disease Virus (2) (RHDV2) and Pasteurellosis (serotypes A:1, A:3, A:12, D:2) using Coral vac RZ ...
Mahmoud Ismail, Samah Abodalal, Amina Radwan   +2 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Towards broad-spectrum protection: the development and challenges of combined respiratory virus vaccines

Frontiers in Cellular and Infection Microbiology
In the post-COVID-19 era, the co-circulation of respiratory viruses, including influenza, SARS-CoV-2, and respiratory syncytial virus (RSV), continues to have significant health impacts and presents ongoing public health challenges.
Yang Wang, Yang Wang, Xiaotong Wei, Yang Liu, Yang Liu, Shengfeng Li, Weiqi Pan, Weiqi Pan, Jun Dai, Jun Dai, Zifeng Yang, Zifeng Yang, Zifeng Yang   +12 more
doaj   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source