Results 151 to 160 of about 301,526 (300)

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Lipid nanoparticle-mediated mRNA/siRNA dual-bioengineered dendritic cell vaccines combined of PD-1/PD-L1 blockade for boosting tumor immunotherapy. [PDF]

Mater Today Bio
Yang D, Zhan J, Miao L, He C, Xu H.
europepmc   +1 more source

Vaccination of Cows with a Combined Rotavirus/Enterotoxigenic "E. Coli" K99 Vaccine to Protect Newborn Calves Against Diarrhoea [PDF]

, 1983
Bachmann, P. A., Baljer, G., Eichhorn, Werner, Plank, P., Schneider, P.   +4 more
core   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae. [PDF]

mSphere
Huang T, Che S, Lv Z, Hao D, Wang R, Yi Q, Mei L, Yuan Y, Zou H, Guo Y, Wang X, Chu Y, Zhao K.   +12 more
europepmc   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Safety, immunogenicity and effect on viral rebound of HTI vaccines combined with a TLR7 agonist in early-treated HIV-1 infection: a randomized, placebo-controlled phase 2a trial. [PDF]

Nat Commun
Bailón L, Moltó J, Curran A, Cadiñanos J, Carlos Lopez Bernaldo de Quirós J, de Los Santos I, Ambrosioni J, Imaz A, Benet S, Suanzes P, Navarro J, González-García J, Busca C, Pérez-Latorre L, Berenguer J, García-Fraile LJ, Mejía-Abril G, Miró JM, Scévola S, Moreno S, Domingo P, Tian Y, Frankot M, Lim D, Cai Y, Vendrame E, Guo S, Wallin JJ, Geleziunas R, SenGupta D, Alarcón-Soto Y, Leal I, Aranguen A, Garcia-Garcia M, McGowan I, Brander C, Arribas JR, Mothe B, AELIX-003 Study Group.   +38 more
europepmc   +1 more source

Vaccines Combined with Immune Checkpoint Antibodies Promote Cytotoxic T-cell Activity and Tumor Eradication. [PDF]

Cancer Immunol Res, 2016
Ali OA, Lewin SA, Dranoff G, Mooney DJ.
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR

Advanced Science, EarlyView.
The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz, Paola Oquist‐Phillips, Noelia de la Cruz, Inés Lera‐Lasso, Laura Castañar, Javier Rojo, Javier Ramos‐Soriano, Ángeles Canales   +7 more
wiley   +1 more source