Results 91 to 100 of about 171,936 (295)

Bacterial vaccines in poultry

Bulletin of the National Research Centre, 2020
Background Poultry bacterial pathogens are mainly controlled by using high-cost sanitary measures and medical treatment. However, the drug-resistant strains of pathogens continuously emerge, and medical treatments are often ineffective.
Nagwa S. Rabie, Zeinab M. S. Amin Girh
doaj   +1 more source

Improving cellular cancer vaccines

, 2010
Immunization with cancer cells is of great demand in anti-cancer therapy. However, current cellular vaccines are inefficient and there are questions regarding their overall safety. We report a simple and straightforward approach for improving of cellular
Petr Lokhov
core  

Recent advances in DNA vaccines for autoimmune diseases

, 2009
Vaccination is one of the most powerful health tools available owing to its ability to confer protection against various diseases. The long-term impact of such protection in terms of public-health savings is nearly incalculable and becomes even more ...
Bonato, Vania L. D., Silva, Celio L., dos Santos-Junior, Rubens R., Vânia LD Bonato, dos Santos-Junior, Rubens R. [UNESP], Sartori, Alexandrina, Celio L Silva, Carlos R Zárate-Bladés, Zarate-Blades, Carlos R., Sartori, Alexandrina [UNESP], Rubens R dos Santos-Júnior, Alexandrina Sartori   +11 more
core   +1 more source

MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization. [PDF]

, 2009
Human infections with highly pathogenic avian influenza viruses of the H5N1 subtype, frequently reported since 2003, result in high morbidity and mortality.
Sutter, G. (Gerd), Sutter Gerd, Rimmelzwaan, Guus F., Osterhaus, A.D.M.E. (Albert), Yasemin Suezer, Gerrie de Mutsert, Suezer, Yasemin, Geert van Amerongen, Löwer, Johannes, Fouchier Ron A. M., Osterhaus, Albert D. M. E., Kreijtz, Joost H. C. M., Mutsert, Gerrie de, Fouchier, Ron A. M., Fouchier, R.A.M. (Ron), Guus F Rimmelzwaan, van den Brand Judith M. A., Löwer Johannes, Johannes Löwer, Kreijtz, J.H.C.M. (Joost), Suezer, Y., Judith M A van den Brand, Suezer Yasemin, Mutsert, G. (Gerrie) de, Amerongen, G. (Geert) van, Rimmelzwaan Guus F., Brand, J.M.A. (Judith) van den, Joost H C M Kreijtz, Sutter, Gerd, Schwantes, Astrid, de Mutsert Gerrie, Brand, Judith M. A. van den, Osterhaus Albert D. M. E., Schwantes Astrid, Scwantes, A. (Astrid), Ron A M Fouchier, van Amerongen Geert, Albert D M E Osterhaus, Gerd Sutter, Astrid Schwantes, Rimmelzwaan, G.F. (Guus), Kreijtz Joost H. C. M., Amerongen, Geert van, Löwer, J.   +43 more
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Co-Immunization with DNA Vaccines Expressing SABP1 and SAG1 Proteins Effectively Enhanced Mice Resistance to Toxoplasma gondii Acute Infection

, 2023
Toxoplasma gondii (T. gondii) has many intermediate hosts, obligately invades nucleated cells, and seriously threatens human and animal health due to a lack of effective drugs and vaccines.
Xiaohan Zhang, Ebtsam Al-Olayan, Ying Feng, Saeed El-Ashram, Na Yang, Ting He, Ran Chen, Xiaoyu Sang, Xiang Li   +8 more
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Progresses in DNA-based heterologous prime-boost immunization strategies

, 2020
Although recombinant DNA and recombinant viral vectors expressing HIV antigens have yielded positive outcomes in animal models, these vaccines have not been effectively translated to humans.
Jackson, Ronald, Boyle, David B, Ranasinghe, Charani   +2 more
core   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza

Background: Influenza remains a persistent public health challenge due to antigenic drift and shift, necessitating vaccines capable of eliciting broad and durable immunity. Hemagglutinin (HA) antigen serves as the critical target for eliciting protective
Bin Wang, Xuanyi Wang, Lu Lu, Guangyue Han, Rong Xiang, Qiao Wang, Mingyue Chen, Duan Ma, Hongzhe Lin, Yiwei Zhong, Najing Cao, Lei Sun, Weiyu Jiang, Yuxuan Jiang, Yan Li   +14 more
core   +1 more source

A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines

, 2016
It has been known since the discovery of DNA vaccines > 20 y ago that DNA vaccines can function as adjuvants. Our recent study reported the involvement of Aim2 as the sensor of DNA vaccines in eliciting Ag-specific Ab responses.
Wang, Shixia, Suschak, John, Fitzgerald, Katherine A, Lu, Shan   +3 more
core   +1 more source