Results 101 to 110 of about 171,936 (295)

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Advances in nucleic acid-based cancer vaccines

Journal of Biomedical Science
Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to the COVID-19 pandemic.
Hung-Chun Liao, Shih-Jen Liu
doaj   +1 more source

Immunogenicity and Potective Efficacy of DNA Vaccination against Actinobacillus pleuropneumoniae Serotype 1 in Mice

, 2012
[[abstract]]Actinobacillus pleuropneumoniae can induce haemorrhagic, fibrinous and necrotic pleuropneumonia in pigs that causes critical economic losses in swine industry. A number of virulence factors have been identified in A.
Chiang, Chung-Hao; Huang, Li-Pu; Yeh, Chien-Ju; Yang, Wen-Jen
core  

Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant

, 2002
To enhance the efficacy of a DNA vaccine against pseudorabies virus (PRV), we evaluated the adjuvant properties of plasmids coding for gamma interferon or interleukin-12, of CpG immunostimulatory motifs, and of the conventional adjuvants ...
Eddie G. te Lintelo, te Lintelo, E.G., Wim J. A. Boersma, Rooij, E.M.A., van, Yolanda E. de Visser, Boersma, WJA, Lintelo, E.G., te, Boersma, W.J.A., Visser, Y.E., de, Hilgers, LAT, Haagmans, Bart, van Rooij, EMA, Bart L. Haagmans, Bianchi, ATJ, Harrie L. Glansbeek, Hilgers, L.A.T., Haagmans, B.L., Glansbeek, H.L., Andre T. J. Bianchi, van Rooij, E.M.A., Glansbeek, HL, Eugene M. A. van Rooij, de Visser, Y.E., Luuk A. T. Hilgers, Bianchi, A.T.J., Lintelo, EG, de Visser, YE   +26 more
core   +1 more source

In Vivo Electroporation Enhances the Immunogenicity of an HIV-1 DNA Vaccine Candidate in Healthy Volunteers [PDF]

, 2011
10.08.12 KB OA publisher, published version ok to add to Spiral.
Schmidt, C, Lorna Clark, Arlene Hurley, Kopycinski Jakub T., David D. Ho, Caskey, M, Clark, L, Hannaman, D, Gilmour Jill, Schlesinger, SJ, Cheeseman Hannah, Hurley Arlene, Smith Carol, Hurley, A, Ho, DD, Cheeseman, H, Ho David D., Caskey Marina, Fast Patricia, Dally, L, Marina Caskey, Gill Dilbinder K., Roselle Vittorino, Vasan, S, Sarah J Schlesinger, Andersen, J, Harriet H Park, Patricia Fast, Bernard Robert, Clark Lorna, Vittorino, R, Gardiner David F., Josephine H Cox, Dilbinder K. Gill, Dally Len, Robert Bernard, Vasan Sandhya, Josephine H. Cox, Jill Gilmour, Claudia Schmidt, Andersen Johanne, Johanne Andersen, Jakub T Kopycinski, Park Harriet H., Cox, JH, Smith, C, David F Gardiner, Gilmour, J, Harriet H. Park, Tony Tarragona-Fiol, Huang Yaoxing, Sarah J. Schlesinger, Len Dally, Gill, DK, Dilbinder K Gill, Cox Josephine H., Bernard, R, Boente-Carrera, M, Boente-Carrera Mar, Hannah Cheeseman, Sandhya Vasan, Carol Smith, Schlesinger Sarah J., Fast, P, Park, HH, Drew Hannaman, Schmidt Claudia, Tarragona-Fiol, T, Kopycinski, JT, Jakub T. Kopycinski, Huang, Y, Mar Boente-Carrera, Gardiner, DF, Yaoxing Huang, Hannaman Drew, Tarragona-Fiol Tony, Dugin, DP, Daniel P. Dugin, Daniel P Dugin, Vittorino Roselle, Dugin Daniel P., David D Ho, David F. Gardiner   +82 more
core   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs.

, 2001
Protection against viral challenge with canine oral papillomavirus (COPV) was achieved by immunisation via particle-mediated DNA delivery (PMDD) of a plasmid encoding the COPV L1 gene to cutaneous and oral mucosal sites in beagle dogs.
Walcott, S., Nicholls, P.K., Thomsen, L., Stanley, M.A., Santos, E.B., Moore, R.A., Parry, N., Gough, G.   +7 more
core  

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models

Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had the Spike protein or domains thereof as the immunogen.
Petros C. Karakousis, Aakanksha R. Kapoor, Avinaash K. Sandhu, Rowan E. Bates, Alannah D. Taylor, Yinan Hui, James T. Gordy, Richard B. Markham, Jacob Meza, Yangchen Li, Styliani Karanika, Tianyin Wang, Elizabeth Glass, Courtney Schill, Jiaqi Zhang, Samuel K. Ayeh, Kaitlyn Fessler   +16 more
core   +1 more source