Results 161 to 170 of about 171,936 (295)

The current landscape and future directions of Lyme disease vaccines. [PDF]

Virulence
Chen Z, He L, Huang X, Liang X, Liu A, Bao F.   +5 more
europepmc   +1 more source

Continuous Purification of mRNA Produced by In Vitro Transcription Using High Performance Countercurrent Membrane Purification

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Messenger ribonucleic acid (mRNA) therapeutics produced by in vitro transcription must be purified to remove residual enzymes and free nucleotides. This study examines the use of high‐performance countercurrent membrane purification (HPCMP) for the purification of mRNA therapeutics based on differences in the rate of diffusion across ...
Ziqiao Wang, Amin Javidanbardan, Ali Behboudi, Andrew L. Zydney   +3 more
wiley   +1 more source

Dynamics of HIV reservoirs following repeated anti-SARS-CoV-2 vaccination. [PDF]

Front Immunol
Lu J, Ahmad A, Chomont N, Costiniuk CT.
europepmc   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Preventive and therapeutic efficacy of mRNA/LNP vaccines encoding HPV16 E6 and E7 in an early-intervention HPV tumor mouse models. [PDF]

Hum Vaccin Immunother
Saithong S, Prompetchara E, Ketloy C, Khawsang C, Tharakhet K, Kaewpang P, Yostrerat N, Wangsoontorn P, Charsangbong K, Lam K, Heyes J, Weissman D, Ruxrungtham K.   +12 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Therapeutic vaccines targeting solid tumors: A series of clinical trial analysis over the past decade. [PDF]

Transl Oncol
Qiu F, Sun Y, Lim DW.
europepmc   +1 more source

DNA fusion gene vaccines

, 2010
Udgivelsesdato: 2010-FebDNA vaccines are versatile and safe, but limited immunogenicity has prevented their use in the clinical setting. Experimentally, immunogenicity may be enhanced by the use of new delivery technologies, by coadministration of ...
Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Holst, Peter Johannes, Bassi, Maria Rosaria   +3 more
core  

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Clinical research progress and challenges of vaccine for human papillomavirus-associated cancers. [PDF]

Hum Vaccin Immunother
Xue L, Li X, Guo X, Xing H, Liu C.
europepmc   +1 more source