Results 181 to 190 of about 161,532 (251)

African Swine Fever: Vaccine Advancement and Major Gaps. [PDF]

Microorganisms
Wang L, Shi J.
europepmc   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Immune protection in chickens via lipid nanoparticle-encapsulated VP2 DNA vaccine against very virulent infectious bursal disease virus. [PDF]

Poult Sci
Zhang Y, Yu H, Wu Z, Wang G, Liu R, Ling D, Ke E, Wang S, Chen Y, Liu Y, Cui H, Zhang Y, Gao Y, Qi X.   +13 more
europepmc   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Lymph node-targeted DNA engages TBK1/IFN-I-driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs. [PDF]

Sci Adv
Steinbuck MP, Seenappa LM, Zhan W, Palmer E, Jung MM, Jakubowski A, Cabana-Puig X, McNeil LK, Haqq CM, Fitzgerald KA, DeMuth PC.   +10 more
europepmc   +1 more source

Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions

Chemistry – A European Journal, EarlyView.
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan, Josef Kapitán, Jiří Kessler, Ondřej Zapletal, Valery Andrushchenko, Petr Bouř   +5 more
wiley   +1 more source

Repurposing COVID-19 (and other) mRNA vaccines to boost cancer immunotherapy efficacy: mechanistic insights and future directions. [PDF]

J Immunother Cancer
Gujar S, Pol JG, Vijayan VV, Gopalakrishnan Nair P, Babukuttan Sheela U, Banerjee A, Kroemer G.   +6 more
europepmc   +1 more source

Spectral, Semi‐Spectral, and Bandwidth Flow Cytometric Implementation of Multiplex Cytokine Bead Assays

Cytometry Part A, EarlyView.
ABSTRACT Multiplex cytokine bead assays (MCBA) have previously been carried out on conventional (aka classical, or bandwidth) flow cytometers, and issues involving unmixing distortions were encountered when using the manufacturer's set‐up beads for unmixing full‐spectrum data.
Jacob Laster, Jenny Hernandez‐Davies, D. Huw Davies, Egest J. Pone   +3 more
wiley   +1 more source

APC-targeted DNA vaccines: the role of CCL19 in immune cell recruitment and early onset of the immune response. [PDF]

Cancer Immunol Immunother
Barrio-Calvo M, Friis S, Kofoed SV, Holste SC, Andersen RO, Rønø B, Hjortø GM.   +6 more
europepmc   +1 more source