Results 181 to 190 of about 171,936 (295)

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

From legacy to innovation: A comprehensive review of vaccine platforms against viral infections. [PDF]

Virus Res
Farsiu N, Khodadadpour Mahani F, Arefinia N, Charostad J, Pardeshenas M, Mirzaei H, Nakhaie M, Hassandarvish P, AbuBakar S.   +8 more
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Vaccines as treatment for melanoma: an update review. [PDF]

Front Immunol
Zhang J, Cao Q, Cen Y, Zhang L, Chen J.
europepmc   +1 more source

Viscosity of concentrated mRNA solutions: Implications for downstream processing

Biotechnology Progress, EarlyView.
Abstract Messenger RNA (mRNA) therapeutics can be used to protect against infectious disease and for the treatment of cancers and genetic disorders. In order to obtain the desired therapeutic dosage, it is necessary to concentrate the mRNA to levels where the viscosity of the mRNA solutions can become significant.
Amin Javidanbardan, Fatemeh Najafi, Ziqiao Wang, Andrew L. Zydney   +3 more
wiley   +1 more source

Heterologous Prime-Boost Vaccination with GRA35-Encoding DNA and mRNA Vaccines Enhances Protective Immunity Against <i>Toxoplasma gondii</i> Infection in Mouse Models. [PDF]

Microorganisms
Chen S, Li R, Zhu Y, Sun J, Chen J.
europepmc   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Modern Strategies for Brucellosis Vaccination: From Traditional Approaches to Innovative Platforms. [PDF]

Vaccines (Basel)
Assanzhanova N, Zhugunissov K, Chervyakova O, Ryskeldinova S, Akmyrzayev N, Sagymbayeva A, Myrzakhmetov Y, Mailybayeva A.   +7 more
europepmc   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Synthetic DNA vaccine platform elicits potent immunity where electroporated naked-mRNA is non-immunogenic. [PDF]

J Immunother Cancer
Tonini C, Bianchi A, Esposito M, Esposito I, Giacomelli T, Young E, Lanckriet H, Whiffen Z, Pavlickova M, Entiriwaa D, Principato E, Roscilli G, Piconese S, Lione L, Salvatori E, Pinto E, Ciliberto G, Aurisicchio L, Walker A, Palombo F.   +19 more
europepmc   +1 more source