Results 201 to 210 of about 166,548 (251)
Establishment of a Neonatal Natural Transmission Model for Cytomegalovirus Vaccine Development. [PDF]
Jihad T +20 more
europepmc +1 more source
Biomarkers for predicting and monitoring the efficacy of cancer vaccines. [PDF]
Remizova JA +5 more
europepmc +1 more source
Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics. [PDF]
Ye L +8 more
europepmc +1 more source
Elicitation of Potent H5N1- and H7N9-Neutralizing Antibody Responses in Rhesus Macaques by Sequential Heterologous Vaccination with mRNA and Adenoviral Vectors Encoding Full-Length Hemagglutinins. [PDF]
Rosen BC +15 more
europepmc +1 more source
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Current Opinion in Immunology, 1996
Preclinical DNA vaccine development has continued apace during the past year, with the investigation of several new infectious and non-infectious disease targets as well as advances in our understanding of some of the basic immunologic mechanisms, such as effector cells, responsible for conferring protection.
J B, Ulmer, J C, Sadoff, M A, Liu
+11 more sources
Preclinical DNA vaccine development has continued apace during the past year, with the investigation of several new infectious and non-infectious disease targets as well as advances in our understanding of some of the basic immunologic mechanisms, such as effector cells, responsible for conferring protection.
J B, Ulmer, J C, Sadoff, M A, Liu
+11 more sources
Annual Review of Immunology, 1997
▪ Abstract  Observations in the early 1990s that plasmid DNA could directly transfect animal cells in vivo sparked exploration of the use of DNA plasmids to induce immune responses by direct injection into animals of DNA encoding antigenic proteins. This method, termed DNA immunization, now has been used to elicit protective antibody and cell-mediated ...
J J, Donnelly +3 more
+11 more sources
▪ Abstract  Observations in the early 1990s that plasmid DNA could directly transfect animal cells in vivo sparked exploration of the use of DNA plasmids to induce immune responses by direct injection into animals of DNA encoding antigenic proteins. This method, termed DNA immunization, now has been used to elicit protective antibody and cell-mediated ...
J J, Donnelly +3 more
+11 more sources
The regulation of DNA vaccines
Current Opinion in Biotechnology, 2001The framework for regulating DNA vaccines has been in place since the first clinical trial was initiated in the mid-1990s. American and European regulatory guidance has evolved on the basis of insights provided by ongoing preclinical and clinical studies.
H A, Smith, D M, Klinman
openaire +2 more sources
DNA Vaccines and Intradermal Vaccination by DNA Tattooing
2010Over the past two decades, DNA vaccination has been developed as a method for the induction of immune responses. However, in spite of high expectations based on their efficacy in preclinical models, immunogenicity of first generation DNA vaccines in clinical trials was shown to be poor, and no DNA vaccines have yet been licensed for human use.
K, Oosterhuis +3 more
openaire +2 more sources
Advanced Drug Delivery Reviews, 2005
The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction ...
Helen S, Garmory +3 more
openaire +2 more sources
The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction ...
Helen S, Garmory +3 more
openaire +2 more sources

