Results 81 to 90 of about 471,639 (303)

Efficacy, Safety, and Immunogenicity of Subunit Respiratory Syncytial Virus Vaccines: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Vaccines
Background: Respiratory syncytial virus (RSV) is garnering increasing attention, with a growing number of subunit RSV vaccines under active clinical investigation. However, comprehensive evidence is limited.
Yuhang Wu, Yuqiong Lu, Yuwei Bai, Bingde Zhu, Feng Chang, Yun Lu   +5 more
doaj   +1 more source

Role of fused Mycobacterium tuberculosis immunogens and adjuvants in modern tuberculosis vaccines

Frontiers in Immunology, 2014
Several approaches have been developed to improve or replace the only available vaccine for tuberculosis (TB), BCG (Bacille Calmette Guerin). The development of subunit protein vaccines is a promising strategy because it combines specificity and safety ...
Ana Paula eJunqueira-Kipnis, Lázaro Moreira Marques Neto, André eKipnis   +2 more
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Enhancing vaccine half-life as a novel strategy for improving immune response durability of subunit vaccines.

PLoS Pathogens
Vaccines are widely regarded as one of the most effective strategies for combating infectious diseases. However, significant challenges remain, such as insufficient antibody levels, limited protection against rapidly evolving variants, and poor immune ...
Zhaoling Shen, Cheng Li, Wenping Song, Litong Liu, Yu Kong, Ailing Huang, Qingui Bao, Tianlei Ying, Yanling Wu   +8 more
doaj   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +1 more source

Advances in Pasteurella multocida Vaccine Development: From Conventional to Next-Generation Strategies

Vaccines
Pasteurella multocida is a Gram-negative bacterium causing significant livestock diseases, like fowl cholera and hemorrhagic septicemia in cattle, and wound infection in humans.
Adehanom Baraki Tesfaye, Geberemeskel Mamu Werid, Zhengyu Tao, Liuchao You, Rui Han, Jiayao Zhu, Lei Fu, Yuefeng Chu   +7 more
doaj   +1 more source

Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances

, 2022
Porcine circovirus type 2 (PCV2) infection can lead to porcine circovirus-associated disease (PCVAD), causing great economic losses to the global swine industry.
Guo, Jinshuo, Jue Liu, Zhou, Jianwei, Liu, Jue, Hou, Lei, Dedong Wang, Yongqiu Cui, Xufei Feng, Lei Hou, Jinshuo Guo, Jianwei Zhou, Cui, Yongqiu, Wang, Dedong, Feng, Xufei   +13 more
core   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Algae-based oral recombinant vaccines

Frontiers in Microbiology, 2014
Recombinant subunit vaccines are some of the safest and most effective vaccines available, but their high cost and the requirement of advanced medical infrastructure for administration make them impractical for many developing world diseases. Plant-based
Elizabeth A Specht, Stephen P Mayfield
doaj   +1 more source