Results 91 to 100 of about 471,639 (303)
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
Molecular Approaches for Improving Subunit Vaccines against [PDF]
, 2013 Infection with Mycobacterium tuberculosis, the causative agent of Tuberculosis (TB), remains responsible for at least 1.5 million deaths annually. BCG is the only currently licensed anti-TB vaccine, however its protective efficacy varies between 0 and 80%
KAO, Fan
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Recombinant subunit vaccines for soil-transmitted helminths
, 2017 SUMMARYSoil-transmitted helminths (STHs) collectively infect one fourth of all human beings, and the majority of livestock in the developing world. These gastrointestinal nematodes are the most important parasites on earth with regard to their prevalence
JASON B. NOON, RAFFI V. AROIAN
core +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi +1 more
wiley +1 more source
Vaccines against avian influenza in poultry
Вопросы вирусологии, 2017 The review presents the latest data about the types of vaccines against avian influenza that are used in current medical practice or are under development.
L. V. Kostina +5 more
doaj +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Understanding protein subunit COVID-19 vaccines [PDF]
Updated July 20, 2022What You Need to Know\u2022 Protein subunit COVID-19 vaccines contain pieces (proteins) of the virus that causes COVID-19; these proteins are called the \u201cspike protein.\u201d\u2022 Protein subunit COVID-19 vaccines also contain ...
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Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis.
, 2005 BACKGROUND: Decisions about the use of killed oral cholera vaccines, which confer moderate levels of direct protection to vaccinees, can depend on whether the vaccines also provide indirect (herd) protection when high levels of vaccine coverage are ...
Ali, Mohammad +10 more
core +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan +11 more
wiley +1 more source