Results 101 to 110 of about 471,639 (303)

Research progress on Haemophilus parasuis vaccines

Frontiers in Veterinary Science
Haemophilus parasuis (HPS) is the causative agent of porcine Glässer’s disease, which has become prevalent in China in recent years. It is characterized by fibrinous polyserositis, arthritis, and meningitis, but often shows mixed infection with other ...
Yu Duan, Yue Hao, Huapeng Feng, Jianhong Shu, Yulong He   +4 more
doaj   +1 more source

Novel approaches to tuberculosis vaccine development

International Journal of Infectious Diseases, 2017
Tuberculosis (TB) remains the deadliest infectious disease. The widely used bacille Calmette–Guérin (BCG) vaccine offers only limited protection against TB.
Stefan H.E. Kaufmann, January Weiner, C. Fordham von Reyn   +2 more
doaj   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Modern subunit vaccines: development, components, and research opportunities

, 2013
Traditional vaccines, based on the administration of killed or attenuated microorganisms, have proven to be among the most effective methods for disease prevention.
Moyle, Peter Michael, Istvan Toth, Toth, Istvan, Peter Michael Moyle   +3 more
core   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Review of advanced research on swine Actinobacillus pleuropneumoniae vaccine development strategy

Frontiers in Immunology
Actinobacillus pleuropneumoniae (App) infection is a major respiratory disease that causes severe economic losses. It is highly infectious and exhibits multiple serotypes, which complicates prevention and control. This review discusses the new-generation
Adehanom Baraki Tesfaye, Adehanom Baraki Tesfaye, Adehanom Baraki Tesfaye, Rui Han, Rui Han, Zhengyu Tao, Zhengyu Tao, Liuchao You, Liuchao You, Jiayao Zhu, Jiayao Zhu, Pengcheng Gao, Pengcheng Gao, Lei Fu, Lei Fu, Yuefeng Chu, Yuefeng Chu   +16 more
doaj   +1 more source

Vaccine profile of herpes zoster (HZ/su) subunit vaccine

Expert Review of Vaccines, 2017
Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age-related or other causes of decreased T cell ...
Anthony L. Cunningham, Thomas Heineman
openaire   +3 more sources

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source

Vaccine Platform-Dependent Differential Impact on Microbiome Diversity: Potential Advantages of Protein Subunit Vaccines

Background: The COVID-19 pandemic accelerated the development of diverse vaccine platforms, including mRNA, adenoviral vector, and protein subunit vaccines. Given the growing evidence that the gut microbiome modulates vaccine-induced immunity, this study
Noh, Ji Yun, Jin Gu Yoon, Hee Jin Cheong, Kim, Woo Joo, Lim, Sooyeon, Cheong, Hee Jin, Choi, Yu Jung, Yu Jung Choi, Yoon, Jin Gu, Nham, Eliel, Joon Young Song, Eliel Nham, Seong, Hye, Hye Seong, Woo Joo Kim, Song, Joon Young, Ji Yun Noh, Sooyeon Lim   +17 more
core   +1 more source