Results 191 to 200 of about 1,877,160 (342)

Biotechnology and the Future of Vaccines-From Novel Routes and Vectors to Safety, Efficacy, and Global Impact. [PDF]

Vaccines (Basel)
Kuo TH, Chen YC.
europepmc   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Editorial: Epitope Discovery and Synthetic Vaccine Design

Frontiers in Immunology, 2018
Clarisa Beatriz Palatnik-de-Sousa, Clarisa Beatriz Palatnik-de-Sousa, Irene da Silva Soares, Daniela Santoro Rosa, Daniela Santoro Rosa   +4 more
doaj   +1 more source

Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization. [PDF]

Front Immunol
Gary EN, Trachtman AR, Wang D, Bharti S, Ye Y, Tursi NJ, Tomirotti M, Eisenhauer J, Chu JD, Zegarra DC, Hojecki CE, Zheng M, Wickramasinghe J, Weiner DB, Patel A.   +14 more
europepmc   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, EarlyView.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

Application progress and biosafety challenges of gene editing and synthetic biotechnology in diagnosis, treatment and prevention of infectious diseases. [PDF]

Biosaf Health
Gao Z, Gao Y, Wang S, Li X, Cao W, Deng W, Yao L, Wei X, Zhang Z, Wang S, Zhang Y, Li M, Xie Y.   +12 more
europepmc   +1 more source

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing. [PDF]

Front Immunol
Talukdar P, Winegar PH, Hudson GA, Astolfi MCT, Inman JL, Keasling JD, Mukundan H.   +6 more
europepmc   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

DNA Vaccines in the Post-mRNA Era: Engineering, Applications, and Emerging Innovations. [PDF]

Int J Mol Sci
Neeli P, Chai D, Roy D, Prajapati S, Bonam SR.   +4 more
europepmc   +1 more source