Results 251 to 260 of about 1,877,160 (342)

Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators

Angewandte Chemie, EarlyView.
The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase   +9 more
wiley   +2 more sources

Advances in Biotechnology and the Development of Novel Human Vaccines. [PDF]

Vaccines (Basel)
Papadatou I, Michos A.
europepmc   +1 more source

Toward Customization of Pickering Emulsion Nanocarriers for Personalized Delivery of Therapeutics in Cancer Treatments: A Review

Advanced NanoBiomed Research, EarlyView.
Pickering emulsion‐based nanocarriers are emerging as a disruptive innovation in oncology. Their unique structural and functional attributes have now positioned these systems at the forefront of next‐generation smart delivery platforms, capable of improving therapeutic precision, efficacy, and safety.
Nutan Shukla, Aayushi Chanderiya, Ratnesh Das, Supriya Vyas, Elizaveta Mukhanova, Alexander Soldatov, Samuel Adeloju   +6 more
wiley   +1 more source

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, EarlyView.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Nanocarrier-based immunotherapy for viral diseases. [PDF]

Int J Pharm X
Liu D, Zhao T, Li Y, Huang L, Che J, Zou P, Yang W, Ding J, Wu P, Gao X, Ran Y, Sun H, Li Z, Gao J, Gao C.   +14 more
europepmc   +1 more source

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang   +10 more
wiley   +1 more source

Chemical Synthesis of Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii Capsular Polysaccharide Fragments as Leads for Cross‐Protection

Angewandte Chemie, EarlyView.
A total of 16 chemically synthesized capsular polysaccharide (CPS) fragments related to Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii were analyzed by glycan microarray. Comparative screening revealed three conserved epitopes that act as cross‐protective vaccine lead candidates against multidrug‐resistant (MDR) bacterial ...
Amar Kumar Mishra, Emelie E. Reuber, Diksha Rai, Leif E. Sander, Julia Duerr, Simon Y. Graeber, Marcus A. Mall, Bettina C. Fries, Peter H. Seeberger, Suvarn S. Kulkarni   +9 more
wiley   +2 more sources

A new combination of 5'- and 3'-untranslated regions increases the expression of mRNAs in vitro and in vivo. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Antropov DN, Markov OV, Dome AS, Puchkov PA, Shmendel EV, Gladkikh DV, Golyshev VM, Matveeva AM, Maslov MA, Stepanov GA.   +9 more
europepmc   +1 more source

Exploring ceRNA mechanisms in COVID-19 mRNA vaccine-induced myocarditis: implications for future vaccine design. [PDF]

Front Immunol
Wang J, Sun XY, Gao Q, Fu M, Xiao M, Du N, Ge XY.   +6 more
europepmc   +1 more source

Carbohydrate Chemistry II. [PDF]

Molecules
Marra A.
europepmc   +1 more source